{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:43:51Z","timestamp":1787697831172,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric Crohn's disease is associated with perianal disease (PAD). Magnetic resonance enterography (MRE) assesses small bowel involvement in pediatric inflammatory bowel disease (PIBD). Pelvic MRI (P\u2010MRI) is the gold standard for assessing PAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine if MRE can accurately detect PAD in PIBD, distinguishing perianal fistulae (PAF) from perianal abscesses (PAA), referenced against P\u2010MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Seventy\u2010seven PIBD patients, 27 females (mean age 14.1 years), with P\u2010MRI and MRE within 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5T and 3T; P\u2010MRI: sagittal fat suppressed (FS) T<jats:sub>2<\/jats:sub> fast spin\u2010echo (FSE), coronal short tau inversion recovery, axial T<jats:sub>1<\/jats:sub> FSE, coronal and axial postcontrast FS T<jats:sub>1<\/jats:sub> FSE; MRE: coronal balanced steady\u2010state free\u2010precession (SSFP), coronal cine SSFP, coronal and axial single\u2010shot T<jats:sub>2<\/jats:sub> FS, axial SSFP, coronal ultrafast 3D T<jats:sub>1<\/jats:sub>\u2010weighted gradient echo FS (3D T<jats:sub>1<\/jats:sub> GE), axial diffusion\u2010weighted imaging, coronal and axial postcontrast 3D T<jats:sub>1<\/jats:sub> GE FS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Two radiologists independently, then by consensus, assessed randomized MRI exams, recording PAF number, location, and length; and PAA number, location, length, and volume. Sensitivity analysis used clinical disease as the gold standard, calculated separately for P\u2010MRI and MRE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Comparing MRE and P\u2010MRI consensus data, sensitivity, specificity, positive, and negative predictive values (P\/NPV) were calculated. Inter\u2010 and intrareader reliability were assessed using kappa statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>P\u2010MRI and MRE were paired, detecting PAD in 73 patients, PAF in 63, and PAA in 31 P\u2010MRI. MRE sensitivities, specificities, PPV, and NPV were: PAD 82%, 100%, 100%, 23%; PAF 74%, 71%, 92%, 38%; PAA 51%, 85%, 69%, 72%; clinical 82%, 22%, 37%, 69%; clinical P\u2010MRI 96%, 8%, 37%, 80%. MRE interreader agreement for PAD was moderate (kappa\u2009=\u20090.51 [0.29\u20130.73]), fair for PAF and PAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Using a standard technique, MRE can detect PAD with high specificity and moderate sensitivity in PIBD, missing some PAF and small PAA.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 3<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:1638\u20131645.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25888","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T12:46:37Z","timestamp":1510663597000},"page":"1638-1645","source":"Crossref","is-referenced-by-count":14,"title":["Can MR enterography screen for perianal disease in pediatric inflammatory bowel disease?"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-951X","authenticated-orcid":false,"given":"Zehour","family":"AlSabban","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Toronto Canada"},{"name":"Department of Medical Imaging University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Carman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahim","family":"Moineddin","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian K.","family":"King","sequence":"additional","affiliation":[{"name":"Division of General and Thoracic Surgery Toronto Canada"},{"name":"The Hospital for Sick Children, Department of Surgery University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C.","family":"Langer","sequence":"additional","affiliation":[{"name":"Division of General and Thoracic Surgery Toronto Canada"},{"name":"The Hospital for Sick Children, Department of Surgery University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Walters","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Church","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Louise C.","family":"Greer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Toronto Canada"},{"name":"Department of Medical Imaging University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000239"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-014-3085-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20767"},{"key":"e_1_2_6_5_1","first-page":"922","article-title":"Perianal Crohn's disease in children and adolescents","volume":"9","author":"Tolia V","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001447"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2391041043"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/624141"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000367"},{"key":"e_1_2_6_10_1","unstructured":"American College of Radiology.ACR Appropriateness Criteria\u00ae 1 Crohn Disease. 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