{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:26:13Z","timestamp":1740104773293,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004330","name":"GSK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Extracellular volume (ECV) by T<jats:sub>1<\/jats:sub> mapping requires the contrast agent distribution to be at equilibrium. This can be achieved either definitively with a primed contrast infusion (infusion ECV), or sufficiently with a delay postbolus (bolus\u2010only ECV). For large ECV, the bolus\u2010only approach measures higher than the infusion ECV, causing some uncertainty in diseases such as amyloidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize the relationship between the bolus\u2010only and current gold\u2010standard infusion ECV in patients with amyloidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Bolus\u2010only and infusion ECV were prospectively measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 186 subjects with systemic amyloidosis attending our clinic and 23 subjects with systemic amyloidosis who were participating in an open\u2010label, two\u2010part, dose\u2010escalation, phase 1 trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength<\/jats:title><jats:p>Avanto 1.5T, Siemens Medical Solutions, Erlangen, Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Bolus\u2010only and infusion ECV were measured in all subjects using shortened modified Look\u2013Locker inversion recovery (ShMOLLI) T<jats:sub>1<\/jats:sub> mapping sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Pearson correlation coefficient (<jats:italic>r<\/jats:italic>); Bland\u2013Altman; receiver operating characteristic (ROC) curve analysis. Linear regression model with a fractional polynomial transformation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The difference between the bolus\u2010only and infusion myocardial ECV increased as the average of the two measures increased, with the bolus\u2010ECV measuring higher. For an average ECV of 0.4, the difference was 0.013. The 95% limits of agreement for the two methods, after adjustment for the bias, were \u00b10.056. However, cardiac diagnostic accuracy was comparable (bolus\u2010only vs. infusion ECV area under the curve [AUC]\u2009=\u20090.839 vs. 0.836), as were correlations with other clinical cardiac measures, and, in the trial patients, the ability to track changes in the liver\/spleen with therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>In amyloidosis, with large ECVs, the bolus\u2010only technique reads higher than the infusion technique, but clinical performance by any measure is the same. Given the work\u2010flow advantages, these data suggest that the bolus\u2010only approach might be acceptable for amyloidosis, and might support its use as a surrogate endpoint in future clinical trials.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 4<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:1677\u20131684.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25907","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T06:18:58Z","timestamp":1511245138000},"page":"1677-1684","source":"Crossref","is-referenced-by-count":7,"title":["Extracellular volume with bolus\u2010only technique in amyloidosis patients: Diagnostic accuracy, correlation with other clinical cardiac measures, and ability to track changes in amyloid load over time"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-3097","authenticated-orcid":false,"given":"Giulia","family":"Zumbo","sequence":"first","affiliation":[{"name":"National Amyloidosis Centre University College London, Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon V.","family":"Barton","sequence":"additional","affiliation":[{"name":"GSK Medicines Research Centre Stevenage 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