{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:49:39Z","timestamp":1790621379613,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation project of China","doi-asserted-by":"crossref","award":["81401386"],"award-info":[{"award-number":["81401386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation project of China","doi-asserted-by":"crossref","award":["81771798"],"award-info":[{"award-number":["81771798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Previous studies indicated that two\u2010dimensional\u2010susceptibility weighted imaging (2D\u2010SWI) could serve as a useful biomarker for differentiating the grade of liver fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>PURPOSE<\/jats:title><jats:p>To evaluate the feasibility of 2D\u2010SWI in the dynamic quantification of renal fibrosis in a rabbit model.<\/jats:p><jats:p><jats:bold>STUDY TYPE<\/jats:bold>: Longitudinal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>ANIMAL MODEL<\/jats:title><jats:p>Twenty\u2010Four New Zealand White Rabbits including control group (n\u2009=\u20094); and renal fibrosis group (n\u2009=\u200920), by means of a unilateral ureteral obstruction (UUO) model.<\/jats:p><\/jats:sec><jats:sec><jats:title>FIELD STRENGTH\/SEQUENCE<\/jats:title><jats:p>The 3.0\u2009T SWI using a 2D gradient\u2010echo sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>ASSESSMENT<\/jats:title><jats:p>The relative SWI signal ratio(r) of cortical and medulla (r\u2009=\u2009SI<jats:sub>renal<\/jats:sub>\/SI<jats:sub>muscle<\/jats:sub>) was longitudinally assessed before ligation and on weeks 2, 4, 6, and 8 following ligation. Sirius Red staining was used to assess the degree of fibrosis in five high\u2010power fields.<\/jats:p><\/jats:sec><jats:sec><jats:title>STATISTICAL TESTS<\/jats:title><jats:p>The repeated measures of analysis of variance and linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Both the cortical and medullary r values were significantly higher in the UUO kidneys at week 2 compared with the kidneys before ligation. Over the course of UUO progression, significant changes occurred in the cortical and medullary r values in vivo and fibrosis scores in vitro (all <jats:italic>P<\/jats:italic> values\u2009&lt;\u20090.05). The r values gradually decreased, while the fibrosis scores gradually increased over 8 weeks following ligation. The linear regression analysis showed a strong and significant correlation between cortical and medullary r values and the pathologic fibrosis scores (R<jats:sup>2<\/jats:sup>\u2009=\u20090.91, 0.81, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>DATA CONCLUSION<\/jats:title><jats:p>The SWI sequence could provide a quantitative evaluation of renal fibrosis during UUO progression.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:1572\u20131577.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25915","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T15:06:04Z","timestamp":1513177564000},"page":"1572-1577","source":"Crossref","is-referenced-by-count":17,"title":["Longitudinal assessment of rabbit renal fibrosis induced by unilateral ureteral obstruction using two\u2010dimensional susceptibility weighted imaging"],"prefix":"10.1002","volume":"47","author":[{"given":"Jing\u2010Gang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology The Third Affiliated Hospital of Soochow University Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Yu","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Soochow University Changzhou 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