{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:08:26Z","timestamp":1782389306102,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571638"],"award-info":[{"award-number":["81571638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Polymyositis (PM) and dermatomyositis (DM) are common types of idiopathic inflammatory myopathy (IIM), wherein patients are prone to adverse cardiovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the value of cardiac magnetic resonance imaging (MRI) for detecting cardiac involvement in PM\/DM patients using a T<jats:sub>1<\/jats:sub> mapping technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 25 PM\/DM patients free of cardiovascular symptoms and preserved ventricular systolic function and 25 healthy volunteers matched for age and sex served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Cardiac MRI at 3T, including steady\u2010state free precession (SSFP) cine imaging, late gadolinium enhancement (LGE), and T<jats:sub>1<\/jats:sub> mapping with modified Look\u2013Locker inversion recovery (MOLLI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Myocardial native T<jats:sub>1<\/jats:sub> and extracellular volume (ECV) of the left ventricle as well as the correlations with disease activity were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Independent sample's <jats:italic>t<\/jats:italic>\u2010test, Fisher's exact test, or chi\u2010square test, Pearson's correlation (<jats:italic>r<\/jats:italic>) were applied. <jats:italic>P<\/jats:italic> \u2264 0.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Left ventricular end\u2010diastolic\/end\u2010systolic volume index (<jats:italic>P<\/jats:italic> = 0.643, <jats:italic>P<\/jats:italic> = 0.325, respectively), mass index (<jats:italic>P<\/jats:italic> = 0.719), and ejection fraction (<jats:italic>P<\/jats:italic> = 0.144) were not significantly different between PM\/DM patients and controls. LGE was found in 19% of PM\/DM patients and none of the control subjects. PM\/DM patients showed significantly higher native T<jats:sub>1<\/jats:sub> values (1263.7 \u00b1 84.0 msec vs. 1200.6 \u00b1 43.0 msec, <jats:italic>P<\/jats:italic> = 0.002) and expanded extracellular volume (ECV) (32.6 \u00b1 3.7% vs. 26.7 \u00b1 2.3%, <jats:italic>P<\/jats:italic> &lt; 0.001) compared with control subjects. ECV values in PM\/DM patients had a high proportion (60%) over the 95% percentile of normal controls. Meanwhile, there was a significant correlation between native T<jats:sub>1<\/jats:sub> (<jats:italic>r<\/jats:italic> = 0.710, <jats:italic>P<\/jats:italic> = 0.0001) or ECV (<jats:italic>r<\/jats:italic> = 0.508, <jats:italic>P<\/jats:italic> = 0.01) and N\u2010terminal prohormone of brain natriuretic peptide (NT\u2010proBNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>T<jats:sub>1<\/jats:sub> mapping of cardiac MRI is valuable to detect subclinical myocardial involvement in PM\/DM patients, and both myocardial native T<jats:sub>1<\/jats:sub> and ECV could serve as early imaging markers for myocardial impairment in PM\/DM.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 3<\/jats:p><jats:p>J. MAGN. RESON. IMAGING 2018;48:415\u2013422.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25945","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T14:34:13Z","timestamp":1515767653000},"page":"415-422","source":"Crossref","is-referenced-by-count":35,"title":["Early detection of myocardial involvement by T<sub>1<\/sub> mapping of cardiac MRI in idiopathic inflammatory myopathy"],"prefix":"10.1002","volume":"48","author":[{"given":"Liuyu","family":"Yu","sequence":"first","affiliation":[{"name":"Cardiology Department, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Sun","sequence":"additional","affiliation":[{"name":"Radiology Department, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbo","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiology Department, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Dong","sequence":"additional","affiliation":[{"name":"Cardiology Department, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Northeast Asia MR Collaboration Siemens Healthcare Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Greiser","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division) University of Pennsylvania Philadelphia, Pennsylvania Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiology Department, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiology Department, West China Hospital Sichuan University Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402225"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.093161"},{"issue":"10","key":"e_1_2_7_4_1","first-page":"1846","article-title":"Adult prevalence of systemic autoimmune rheumatic diseases (SARDs) in British Columbia, Canada","volume":"63","author":"Avina\u2010Zubieta JA","year":"2011","journal-title":"Can Arthritis Rheum"},{"key":"e_1_2_7_5_1","first-page":"686","article-title":"Cardiac involvement in adult polymyositis or dermatomyositis: a systematic review","volume":"35","author":"Zhang L","year":"2012","journal-title":"Clin Cardiol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.08.013"},{"key":"e_1_2_7_7_1","article-title":"Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies","author":"Schwartz; 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