{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:42:58Z","timestamp":1790458978530,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,8]]},"abstract":"\n Background<\/jats:title>\n Lung disease is the most frequent cause of morbidity and mortality in patients with cystic fibrosis (CF), and there is a shortage of sensitive biomarkers able to regionally monitor disease progression and to assess early responses to therapy.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To determine the feasibility of noncontrast\u2010enhanced multivolume MRI, which assesses intensity changes between expiratory and inspiratory breath\u2010hold images, to detect and quantify regional ventilation abnormalities in CF lung disease, with a focus on the structure\u2013function relationship.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n Twenty\u2010nine subjects, including healthy young children (\n n<\/jats:italic>\n \u2009=\u20099, 7\u201337 months), healthy adolescents (\n n<\/jats:italic>\n \u2009=\u20094, 14\u201322 years), young children with CF lung disease (\n n<\/jats:italic>\n \u2009=\u200910, 7\u201347 months), and adolescents with CF lung disease (\n n<\/jats:italic>\n \u2009=\u20096, 8\u201318 years) were studied.\n <\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3D spoiled gradient\u2010recalled sequence at 1.5T.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n \n Subjects were scanned during breath\u2010hold at functional residual capacity (FRC) and total lung capacity (TLC) through noncontrast\u2010enhanced MRI and CT. Expiratory\u2010inspiratory differences in MR signal\u2010intensity (\u0394\n 1<\/jats:sup>\n H\u2010MRI) and CT\u2010density (\u0394HU) were computed to estimate regional ventilation. MR and CT images were also evaluated using a CF\u2010specific scoring system.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n Quadratic regression, Spearman's correlation, one\u2010way analysis of variance (ANOVA).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \u0394\n 1<\/jats:sup>\n H\u2010MRI maps were sensitive to ventilation heterogeneity related to gravity dependence in healthy lung and to ventilation impairment in CF lung disease. A high correlation was found between MRI and CT ventilation maps (R\n 2<\/jats:sup>\n \u2009=\u20090.79,\n P<\/jats:italic>\n \u2009<\u20090.001). Globally, \u0394\n 1<\/jats:sup>\n H\u2010MRI and \u0394HU decrease with increasing morphological score (respectively, R\n 2<\/jats:sup>\n \u2009=\u20090.56,\n P<\/jats:italic>\n \u2009<\u20090.001 and R\n 2<\/jats:sup>\n \u2009=\u20090.31,\n P<\/jats:italic>\n \u2009<\u20090.001). Locally, \u0394\n 1<\/jats:sup>\n H\u2010MRI was higher in healthy regions (median 15%) compared to regions with bronchiectasis, air trapping, consolidation, and to segments fed by airways with bronchial wall thickening (\n P<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Multivolume noncontrast\u2010enhanced MRI, as a nonionizing imaging modality that can be used on nearly any MRI scanner without specialized equipment or gaseous tracers, may be particularly valuable in CF care, providing a new imaging biomarker to detect early alterations in regional lung structure\u2013function.<\/jats:p>\n \n Level of Evidence<\/jats:bold>\n : 3\n <\/jats:p>\n \n Technical Efficacy<\/jats:bold>\n : Stage 3\n <\/jats:p>\n J. MAGN. RESON. IMAGING 2018;48:531\u2013542.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.25978","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:18:18Z","timestamp":1518999498000},"page":"531-542","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of pulmonary structure\u2013function relationships in young children and adolescents with cystic fibrosis by multivolume proton\u2010MRI and CT"],"prefix":"10.1002","volume":"48","author":[{"given":"Francesca","family":"Pennati","sequence":"first","affiliation":[{"name":"Dipartimento di Elettronica Informazione e Bioingegneria, Politecnico di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Roach","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Pulmonary Medicine, Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Clancy","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Brody","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Fleck","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Aliverti","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica Informazione e Bioingegneria, Politecnico di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Pulmonary Medicine, Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60327-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90148-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00079010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2014.951333"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e318074fd81"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.02.045"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2015.0588"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0588"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20051"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22724"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.07.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-106"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132470"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00050112"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2971"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.005"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(89)90156-X"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2013.05.032"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_5_21_1","unstructured":"About MIPAV.Center for Information Technology.National Institutes of Health.http:\/\/mipav.cit.nih.gov\/Published March 14 2007. 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