{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:14:07Z","timestamp":1785798847401,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3E1321"],"award-info":[{"award-number":["CMRPG3E1321"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CPRPG3G0021"],"award-info":[{"award-number":["CPRPG3G0021"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["IRB 104\u20104143B"],"award-info":[{"award-number":["IRB 104\u20104143B"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["MOST 104\u20102314\u2010B\u2010182A\u2010095\u2010MY3"],"award-info":[{"award-number":["MOST 104\u20102314\u2010B\u2010182A\u2010095\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Assessment of tumor extent and lymphatic metastasis of uterine carcinosarcomas is important for treatment planning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose\/Hypothesis<\/jats:title><jats:p>To evaluate the diagnostic accuracy of 3.0T diffusion\u2010weighted (DW) MRI for patients with uterine carcinosarcoma, in assessment of tumor extent and lymphatic metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective diagnostic accuracy study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A consecutive cohort of 68 patients with pathologically proved carcinosarcoma between January 2006 and July 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T DW MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Maximal tumor and uterus size, presence of deep myometrial invasion, cervical invasion, adnexal invasion, lymphadenopathy, and the apparent diffusion coefficient (ADC) values of each tumor were used. Histopathology was the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Diagnostic accuracy. Logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 38 patients entered the final analysis, with median age of 58 years (range, 35\u201379 years). The sensitivity and specificity in detecting deep myometrial invasion, cervical stromal invasion, adnexal invasion, as well as pelvic and para\u2010aortic lymph node metastases were 65% and 72%, 91% and 85%, 50% and 100%, 33% and 89%, and 33% and 100%, respectively. The largest tumor diameters predicted deep myometrium invasion (anteroposterior direction, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) and cervical stroma invasion (craniocaudal direction, <jats:italic>P<\/jats:italic>\u2009=\u20090.008). Tumor ADC<jats:sub>min<\/jats:sub> significantly predicted the lymphovascular permeation (<jats:italic>P<\/jats:italic>\u2009=\u20090.025; odds ratio\u2009=\u20090.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Preoperative DW MRI is useful to assess deep myometrial or cervical stromal invasion in uterine carcinosarcoma, yet the diagnostic performance for detecting adnexal invasion and lymphatic metastasis requires further improvement.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 3<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;48:622\u2013631.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25981","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T15:58:59Z","timestamp":1518537539000},"page":"622-631","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic accuracy of 3.0T diffusion\u2010weighted MRI for patients with uterine carcinosarcoma: Assessment of tumor extent and lymphatic metastasis"],"prefix":"10.1002","volume":"48","author":[{"given":"Yu\u2010Ting","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging and Intervention, Imaging Core Laboratory, Institute for Radiological Research Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"},{"name":"Department of Diagnostic Radiology Chang Gung Memorial Hospital at Keelung Keelung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Bi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Imaging Core Laboratory, Institute for Radiological Research Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Ju","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-1058","authenticated-orcid":false,"given":"Gigin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Imaging Core Laboratory, Institute for Radiological Research Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"},{"name":"Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou Gueishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei\u2010Jean","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecologyand Gynecologic Cancer Research Center Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Chieh","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Imaging Core Laboratory, Institute for Radiological Research Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"},{"name":"Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou Gueishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon\u2010Kwan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Imaging Core Laboratory, Institute for Radiological Research Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"},{"name":"Department of Diagnostic Radiology Chang Gung Memorial Hospital at Keelung Keelung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Center for Advanced Molecular Imaging and Translation (CAMIT), Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyong\u2010Huey","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecologyand Gynecologic Cancer Research Center Chang Gung Memorial Hospital at Linkou and Chang Gung University Gueishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-015-0370-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e328349a45b"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.05.016"},{"key":"e_1_2_6_5_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology: Uterine Cancers.National Comprehensive Cancer NetworkWeb site.http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/uterine.pdfAccessed January 6 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