{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:20:38Z","timestamp":1784845238110,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DK08787"],"award-info":[{"award-number":["1R01DK08787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008980","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Radiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2ZHP3_161691"],"award-info":[{"award-number":["P2ZHP3_161691"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Portal hypertension (PH), defined by hepatic venous pressure gradient (HVPG) \u22655 mmHg and clinically significant PH, defined by HVPG \u226510 mmHg, are complications of chronic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the diagnostic performance of MR elastography (MRE) and dynamic contrast\u2010enhanced MRI (DCE\u2010MRI) of the liver and spleen for the prediction of PH and clinically significant PH, in comparison with a qualitative PH imaging scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>IRB\u2010approved prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 34 patients with chronic liver disease who underwent HVPG measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5\/3T examination including 2D\u2010GRE MRE (<jats:italic>n<\/jats:italic>\u2009=\u200933) and DCE\u2010MRI of the liver\/spleen (<jats:italic>n<\/jats:italic>\u2009=\u200928).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Liver and spleen stiffness were calculated from elastogram maps. DCE\u2010MRI was analyzed using model\u2010free parameters and pharmacokinetic modeling. Two observers calculated qualitative PH imaging scores based on routine images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Imaging parameters were correlated with HVPG. Receiver operating characteristic (ROC) analysis was performed for prediction of PH and clinically significant PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant correlations between DCE\u2010MRI parameters (liver time\u2010to\u2010peak, <jats:italic>r<\/jats:italic>\u2009=\u20090.517 \/ <jats:italic>P<\/jats:italic>\u2009=\u20090.006, liver distribution volume, <jats:italic>r<\/jats:italic>\u2009=\u20090.494 \/ <jats:italic>P<\/jats:italic>\u2009=\u20090.009, liver upslope, <jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.567 \/ <jats:italic>P<\/jats:italic>\u2009=\u20090.002), liver stiffness (<jats:italic>r<\/jats:italic>\u2009=\u20090.478 \/ <jats:italic>P<\/jats:italic>\u2009=\u20090.016), PH imaging score (<jats:italic>r<\/jats:italic>\u2009=\u20090.441 \/ <jats:italic>P<\/jats:italic>\u2009=\u20090.009), and HVPG. ROC analysis provided significant area under the ROC (AUROCs) for PH (liver upslope 0.765, liver stiffness 0.809, spleen volume\/diameter 0.746\u20130.731, PH imaging score 0.756) and for clinically significant PH (liver and spleen perfusion parameters 0.733\u20130.776, liver stiffness 0.742, PH imaging score 0.742). The ratio of liver stiffness to liver upslope had the highest AUROC for diagnosing PH (0.903) and clinically significant PH (0.785).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>These preliminary results suggest that the combination of liver stiffness and perfusion metrics provide excellent accuracy for diagnosing PH, and fair accuracy for clinically significant PH. Combined MRE and DCE\u2010MRI outperformed qualitative imaging scores for prediction of PH.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;48:1091\u20131103.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26026","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T11:49:49Z","timestamp":1523447389000},"page":"1091-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Noninvasive prediction of portal pressure with MR elastography and DCE\u2010MRI of the liver and spleen: Preliminary results"],"prefix":"10.1002","volume":"48","author":[{"given":"Mathilde","family":"Wagner","sequence":"first","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Sorbonne Universit\u00e9s, CNRS, INSERM, LIB, Department of Radiology H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, Assistance Publique\u2010H\u00f4pitaux de Paris Paris 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