{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:58:48Z","timestamp":1772063928863,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although diffusion\u2010weighted imaging (DWI) has been characterized as an alternative imaging modality for gallbladder (GB) lesions, it has not been routinely used in clinical practice because of relatively low signal\u2010to\u2010noise ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the sensitivity and specificity of the diagnostic performance of DWI for differentiating benign and malignant GB lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Patients with GB lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>DWI at 3.0T or 1.5T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>PubMed and EMBASE were searched following the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses of Diagnostic Test Accuracy guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Bivariate modeling and hierarchical summary receiver operating characteristic (HSROC) modeling were performed to compare the overall diagnostic performance of DWI. Subgroup analyses were performed for qualitative and quantitative assessment of the DWI. Meta\u2010regression analyses were performed according to the characteristics of the patients, study, and MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies (including 557 patients) were included. The DWI exhibited a pooled sensitivity of 91%, a pooled specificity of 87%, and HSROC of 0.95. In subgroup analyses, qualitative assessment (sensitivity, 90%; specificity, 87%; HSROC, 0.94) was more accurate than quantitative assessment (sensitivity, 82%; specificity, 86 %; HSROC, 0.88). On meta\u2010regression analysis, studies that used 3.0T field strength and thinner slices (\u22645 mm) reported a significantly higher sensitivity (<jats:italic>P<\/jats:italic> \u2264 0.02) than those using only 1.5T field strength and thicker slices (&gt;5 mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>DWI can discriminate malignant from benign GB lesions with excellent diagnostic performance in both qualitative and quantitative assessments. To enhance the diagnostic ability of DWI, images obtained with thinner slices (\u22645 mm) with 3T field strength and qualitative assessment are recommended.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 3<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:1375\u20131388.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26035","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T15:09:05Z","timestamp":1524236945000},"page":"1375-1388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic performance of diffusion\u2010weighted imaging for differentiating benign and malignant gallbladder lesions: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"48","author":[{"given":"Myung\u2010Won","family":"You","sequence":"first","affiliation":[{"name":"Department of Radiology Kyung Hee University Hospital Dongdaemun\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-5701","authenticated-orcid":false,"given":"Seong Jong","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kyung Hee University Hospital at Gangdong Kyung Hee University School of Medicine Gangdong\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"692","article-title":"Diffusion\u2010weighted MRI for differential diagnosis in gallbladder lesions with special reference to ADC cut\u2010off values","volume":"60","author":"Yoshioka M","year":"2013","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3599"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2010.100234"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1918"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1403"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23956"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0235-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2015.16.6.1175"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2015.16.6.1188"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2016.17.1.5"},{"key":"e_1_2_6_14_1","unstructured":"HigginsJ GreenS.Cochrane handbook for systematic reviews of interventions. 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