{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:42:04Z","timestamp":1694947324748},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471723","No.81471723"],"award-info":[{"award-number":["81471723","No.81471723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Multicystic mucinous adenocarcinoma is rarely recognized and has a high misdiagnosis rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To distinguish malignant multicystic mucinous adenocarcinomas from benign multicystic lesions in the uterine cervix using multiparametric MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Forty patients with seven cystic mucinous adenocarcinomas and 33 benign multicystic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T. Diffusion\u2010weighted images (DWI) and dynamic contrast\u2010enhanced (DCE) images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Lesion size, intracystic hemorrhage, solid component, and heterogeneous enhancement were subjectively assessed, and apparent diffusion coefficient (ADC) values, K<jats:sub>trans<\/jats:sub>, K<jats:sub>ep<\/jats:sub>, and V<jats:sub>e<\/jats:sub> parameters were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Analysis<\/jats:title><jats:p>Student's <jats:italic>t<\/jats:italic>\u2010test was used to compare age, tumor size, ADC values, and DCE parameters. Pearson's chi\u2010square test was used to compare intracystic hemorrhage, solid component, and heterogeneous enhancement. Receiver\u2010operating\u2010characteristic (ROC) analysis of ADC values, tumor size, and K<jats:sub>trans<\/jats:sub> were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The size of mucinous adenocarcinomas was larger than benign multicystic lesions (4.09\u2009\u00b1\u20092.09 vs. 2.23\u2009\u00b1\u20090.58\u2009cm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); the area under the curve (AUC) for tumor size was 0.859 with a sensitivity of 71.4% and specificity of 90.9%. Stromal ADC value was lower for mucinous adenocarcinomas (1.19\u2009\u00b1\u20090.22 vs. 1.68\u2009\u00b1\u20090.22 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); AUC for stromal ADC value was 0.970, with a sensitivity of 86.4% and specificity of 100.0%. Among quantitative DCE parameters, only k<jats:sub>trans<\/jats:sub> offered a discriminative value (1.72\u2009\u00b1\u20091.42 vs. 0.69\u2009\u00b1\u20090.30\u2009min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009=\u20090.031); the AUC for k<jats:sub>trans<\/jats:sub> was 0.831 with a sensitivity of 71.4% and specificity of 97.0%. Intracystic hemorrhage (3\/7), solid component (5\/7), and heterogeneous enhancement (4\/7) were only found in mucinous adenocarcinomas. Five patients (71.4%) had lymphovascular space invasion and three (42.9%) had lymph node metastasis. The 1\u2010year tumor recurrence or metastasis rate was 28.5% (2\/7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Awareness of multiparametric MR features can assist in the differentiation of mucinous adenocarcinomas from benign multicystic lesions.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 4<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:1336\u20131343.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26038","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T23:00:12Z","timestamp":1523055612000},"page":"1336-1343","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multicystic mucinous adenocarcinoma of the uterine cervix compared with benign multicystic lesions: Multiparametric MR features"],"prefix":"10.1002","volume":"48","author":[{"given":"Jiacheng","family":"Song","sequence":"first","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiming","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanlong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2012.120059"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0493-RA"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31829c2d66"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213434.91868.b0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.08.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.204.1.9205220"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-7071(98)00089-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.232025065"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.344140001"},{"key":"e_1_2_7_12_1","first-page":"167","article-title":"Benign and malignant orbital lymphoproliferative disorders: Differentiating using multiparametric MRI at 3.0T","author":"Xu XQ","year":"2016","journal-title":"J Magn Reson Imaging"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01462.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2016.08.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821534b9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.03.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31829c2d66"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.3.8109515"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-168"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9713"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.05.001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4583-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.11.007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24894"},{"key":"e_1_2_7_25_1","first-page":"2305","article-title":"Angiogenic activity of cervical carcinoma: assessment by functional magnetic resonance imaging\u2010based parameters and a histomorphological approach in correlation with disease outcome","volume":"4","author":"Hawighorst H","year":"1998","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.11.003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2504-4"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.26038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T19:18:44Z","timestamp":1694891924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.26038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/jmri.26038"],"URL":"https:\/\/doi.org\/10.1002\/jmri.26038","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]},"assertion":[{"value":"2017-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}