{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:51:29Z","timestamp":1781700689604,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Industry Special Scientific Research Project","award":["201402019 (to Z.J.)"],"award-info":[{"award-number":["201402019 (to Z.J.)"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Compressed\u2010sensing (CS) accelerated 3D MR cholangiopancreatography (MRCP) could be acquired in both navigator\u2010triggered (NT) and breath\u2010hold (BH) mode, but the latter has been considered inferior in depicting pancreatic duct and diagnosing pancreatic duct\u2010related diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To prospectively evaluate the clinical feasibility of a modified 3D BH\u2010CS\u2010MRCP prototype protocol with small field\u2010of\u2010view (FOV) and higher spatial resolution, and to compare its performance to the original BH\u2010CS\u2010MRCP and NT\u2010CS\u2010MRCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eighty\u2010two patients with suspected pancreaticobiliary diseases (46 male, median age, 55 years, range, 16\u201379 years), including seven noncooperative patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T, CS\u2010MRCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Three protocols were performed in random order in each patient. Acquisition time of each protocol was recorded. Image quality, background suppression, duct visibility, and diagnostic confidence with duct anatomic variations and duct\u2010related pathologies were rated on a 5\u2010point scale by two blinded radiologists independently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The Wilcoxon signed\u2010rank test was used to compare the intraindividual difference. Interobserver agreement was determined using kappa coefficients. The diagnostic performance was calculated using receiver operating characteristic curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acquisition time was 17 seconds for both BH\u2010CS\u2010MRCP protocols, and 127.5 \u00b1 36.9 seconds for NT\u2010CS\u2010MRCP. In 75 cooperative patients, the incidence of major artifacts was low for all protocols (5.3\u20138.0%). Background suppression was similar with the two BH\u2010CS\u2010MRCP protocols (3.67 \u00b1 0.77 for original BH\u2010CS\u2010MRCP and 3.70 \u00b1 0. 57 for modified BH\u2010CS\u2010MRCP, respectively), both inferior to the NT\u2010CS\u2010MRCP protocol (4.41 \u00b1 0.68, <jats:italic>P<\/jats:italic> &lt; 0.001 for both). Modified BH\u2010CS\u2010MRCP and NT\u2010CS\u2010MRCP depicted pancreatic duct and second\u2010level branches of biliary duct better than original BH\u2010CS\u2010MRCP (all <jats:italic>P<\/jats:italic> &lt; 0.01). The diagnostic performance for detecting bile duct abnormalities was similar for all protocols (<jats:italic>P<\/jats:italic> = 0.53\u20130.87), whereas for detecting pancreatic duct abnormalities, modified BH\u2010CS\u2010MRCP and NT\u2010CS\u2010MRCP had significantly better performance compared to original BH\u2010CS\u2010MRCP (both <jats:italic>P<\/jats:italic> &lt; 0.01). In seven noncooperative patients, NT\u2010CS\u2010MRCP had superior image quality than both BH protocols (both <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Modified BH\u2010CS\u2010MRCP is feasible for pancreatic and biliary disorders. NT\u2010CS\u2010MRCP might be more useful in noncooperative patients.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:1389\u20131399.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26049","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T01:32:11Z","timestamp":1523755931000},"page":"1389-1399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Modified breath\u2010hold compressed\u2010sensing 3D MR cholangiopancreatography with a small field\u2010of\u2010view and high resolution acquisition: Clinical feasibility in biliary and pancreatic disorders"],"prefix":"10.1002","volume":"48","author":[{"given":"Liang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huadan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Qian","sequence":"additional","affiliation":[{"name":"MR collaborations NE Asia Siemens Healthcare Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Weiland","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kuehn","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Asbach","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9, Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9, Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital Beijing 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