{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:48:47Z","timestamp":1790621327202,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Advanced renal disease is characterized by adverse changes in renal structure; however, noninvasive techniques to diagnose and monitor these changes are currently lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the reproducibility of native T<jats:sub>1<\/jats:sub> mapping for renal tissue characterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Reproducibility study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fifteen healthy volunteers (mean age 31 years, range 19\u201363 years), and 11 patients with diabetic nephropathy (mean age 57 years, range 51\u201369 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T, modified Look\u2013Locker imaging (MOLLI) 5(3)3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Intra\u2010 and interexamination reproducibility of voxel\u2010based T<jats:sub>1<\/jats:sub> relaxation times of renal cortex and medulla was assessed in healthy human volunteers and diabetic nephropathy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Reproducibility was evaluated using Bland\u2013Altman and intraclass correlation coefficients (ICCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010 and interexamination reproducibility of renal native T<jats:sub>1<\/jats:sub> mapping showed good\u2013strong ICCs (0.83\u20130.89) for renal cortex and medulla, and moderate\u2013good ICCs (0.62\u20130.81) for cortex\u2013medulla ratio in both healthy volunteers and diabetic nephropathy patients. Intra\u2010 and interexamination limits of agreement were respectively (\u2013124 msec,\u2009+\u200982 msec) and (\u2013134 msec,\u2009+\u200998 msec) for renal cortex and (\u2013138 msec,\u2009+\u2009107 msec) and (\u2013118 msec,\u2009+\u2009151 msec) for medulla. Overall T<jats:sub>1<\/jats:sub> values for renal cortex (<jats:italic>P<\/jats:italic>\u2009=\u20090.277) and medulla (<jats:italic>P<\/jats:italic>\u2009=\u20090.973) were not significantly different between healthy volunteers and diabetic nephropathy patients, in contrast to the cortex\u2013medulla ratio (<jats:italic>P<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Renal native T<jats:sub>1<\/jats:sub> mapping is a technique with good\u2013strong intra\u2010 and examination reproducibility in both healthy volunteers and diabetic nephropathy patients.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 3<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;49:588\u2013596.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26207","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T17:59:06Z","timestamp":1535824746000},"page":"588-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Reproducibility of native T<sub>1<\/sub> mapping for renal tissue characterization at 3T"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-0660","authenticated-orcid":false,"given":"Ilona A.","family":"Dekkers","sequence":"first","affiliation":[{"name":"Department of Radiology Leiden University Medical Center and Leiden University  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth H.M.","family":"Paiman","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center and Leiden University  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko P.J.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Leiden University Medical Center and Leiden University  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildo J.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center and Leiden University  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00094-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.426"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.44"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.11.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3250-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000205"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173248"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30088"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4943-4"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-2"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20110"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-63"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.1.1.30"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20878"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.49"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432465"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01747747"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00640114"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80312-X"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60178-5"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140296"}],"container-title":["Journal 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