{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:28:26Z","timestamp":1791430106478,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Most studies assessing interreader agreement of Prostate Imaging Reporting and Data System v. 2 (PI\u2010RADS v2) have used biopsy as the standard of reference, thus carrying the risk of not definitively noting all existent cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the interreader agreement in assessing prostate cancer (PCa) of PI\u2010RADS v2, using whole\u2010mount histology as the standard of reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Monocentric prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 48 patients with biopsy\u2010proven PCa referred for radical prostatectomy, undergoing staging multiparametric magnetic resonance imaging (mpMRI) between May 2016 to February 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T system using high\u2010resolution T<jats:sub>2<\/jats:sub>\u2010weighted imaging, diffusion\u2010weighted imaging (echo\u2010planar imaging with maximum b\u2010value 2000 sec\/mm<jats:sup>2<\/jats:sup>), and dynamic contrast\u2010enhanced imaging (T<jats:sub>1<\/jats:sub>\u2010weighted high resolution isotropic volume examination; THRIVE)<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Three radiologists blinded to final histology (2\u20138 years of experience) analyzed mpMRI images independently, scoring imaging findings in accordance with PI\u2010RADS v2. On a per\u2010lesion basis, we calculated overall and pairwise interreader agreement in assigning PI\u2010RADS categories, as well as assessing malignancy with categories \u22653 or \u22654, and stage \u2265pT3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Cohen's kappa analysis of agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On 71 lesions found on histology, there was moderate agreement in assigning PI\u2010RADS categories to all cancers (k\u2009=\u20090.53) and clinically significant cancers (csPCa) (k\u2009=\u20090.47). Assessing csPCa with PI\u2010RADS \u22654 cutoff provided higher agreement than PI\u2010RADS \u22653 cutoff (k\u2009=\u20090.63 vs. 0.57). Interreader agreement was higher between more experienced readers, with the most experienced one achieving the highest cancer detection rate (0.73 for csPCa using category \u22654). There was substantial agreement in assessing stage \u2265pT3 (k\u2009=\u20090.72).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>We found moderate to substantial agreement in assigning the PI\u2010RADS v2 categories and assessing the spectrum of cancers found on whole\u2010mount histology, with category 4 as the most reproducible cutoff for csPCa. Readers' experience influenced interreader agreement and cancer detection rate.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;49:546\u2013555.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26220","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T06:59:08Z","timestamp":1536217148000},"page":"546-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Interreader agreement of PI\u2010RADS v. 2 in assessing prostate cancer with multiparametric MRI: A study using whole\u2010mount histology as the standard of reference"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-5147","authenticated-orcid":false,"given":"Rossano","family":"Girometti","sequence":"first","affiliation":[{"name":"Institute of Diagnostic Radiology Department of Medicine Udine UD Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Giannarini","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic Radiology Department of Medicine Udine UD 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