{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:31:26Z","timestamp":1760596286521,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Municipal Commission of Health and Family Planning Excellent Young Talent Program","award":["2017YQ031"],"award-info":[{"award-number":["2017YQ031"]}]},{"name":"Renji Hospital Clinical Training Fund","award":["PYEY16-001"],"award-info":[{"award-number":["PYEY16-001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The use of native T<jats:sub>1<\/jats:sub> mapping for evaluation of hypertrophic cardiomyopathy (HCM) is being explored, and its combination with histogram analysis may benefit the accuracy of such assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the relationship of segmental left ventricular wall thickness (LVWT), myocardial fibrosis, and strain parameters with segmental histogram parameters of native T<jats:sub>1<\/jats:sub> mapping in HCM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Ninety\u2010three HCM patients without previous cardiovascular diseases were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T cardiac MR. Steady\u2010state free precession cine imaging, modified Look\u2013Locker inversion recovery, phase\u2010sensitive inversion recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Images were assessed by three experienced radiologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010tests, area under the curve (AUC), Spearman's rank correlation, intraclass correlation coefficient, and Bland\u2013Altman test were used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher LVWT value correlated with higher means, minimums, 10<jats:sup>th<\/jats:sup>\/25<jats:sup>th<\/jats:sup>\/50<jats:sup>th<\/jats:sup>\/75<jats:sup>th<\/jats:sup>\/90<jats:sup>th<\/jats:sup> percentiles, maximums, kurtosis, entropy, and lower SD and energy of T<jats:sub>1<\/jats:sub> mapping (<jats:italic>P<\/jats:italic> &lt; 0.05 for all), with the correlation being stronger for entropy and energy (Spearman's rho\u2009=\u20090.439 and \u20130.413, respectively) than other parameters. Late gadolinium enhancement positive (LGE+) segments exhibited higher mean, minimum, 10<jats:sup>th<\/jats:sup>\/25<jats:sup>th<\/jats:sup>\/50<jats:sup>th<\/jats:sup>\/75<jats:sup>th<\/jats:sup>\/90<jats:sup>th<\/jats:sup> percentiles, maximum, entropy, and lower energy of T<jats:sub>1<\/jats:sub> times than late gadolinium enhancement negative (LGE\u2013) segments (<jats:italic>P<\/jats:italic> &lt; 0.001 for all). Impaired strain function parameters (peak thickening and thickening rate in radial, circumferential, and longitudinal directions) demonstrated a weak correlation with higher entropy (<jats:italic>P<\/jats:italic> &lt; 0.001 for all) and lower energy (<jats:italic>P<\/jats:italic> &lt; 0.001 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Histogram parameters of native T<jats:sub>1<\/jats:sub> mapping provide more information than mean T<jats:sub>1<\/jats:sub> times alone. Among these parameters, entropy and energy may correlate better with LVWT, myocardial late gadolinium enhancement, and strain parameters than mean T<jats:sub>1<\/jats:sub> times in HCM patients.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage<\/jats:bold>: 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;49:668\u2013677.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26272","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T07:11:07Z","timestamp":1535094667000},"page":"668-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histogram Analysis of Native T<sub>1<\/sub> Mapping and Its Relationship to Left Ventricular Late Gadolinium Enhancement, Hypertrophy, and Segmental Myocardial Mechanics in Patients With Hypertrophic Cardiomyopathy"],"prefix":"10.1002","volume":"49","author":[{"given":"Chong\u2010Wen","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo\u2010Yang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Aolei","family":"An","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital School of Medicine, Shanghai Jiao Tong University  Shanghai P.R. 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