{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:21:56Z","timestamp":1789611716033,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Autosomal dominant polycystic kidney disease (ADPKD) can involve prostate and seminal vesicles but the potential interrelationship of these findings and associations with PKD gene mutation locus and type is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the interrelationship of seminal megavesicles (seminal vesicles with lumen diameter &gt; 10mm) and prostatic cysts in ADPKD and to determine whether there are associations with PKD gene mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective, case control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Male ADPKD subjects (<jats:italic>n<\/jats:italic>\u2009=\u200992) with mutations in <jats:italic>PKD1<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u200971; 77%) or <jats:italic>PKD2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u200921; 23%), and age\/gender\u2010matched controls without ADPKD (<jats:italic>n<\/jats:italic>\u2009=\u200992).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5T, axial\/coronal T<jats:sub>2<\/jats:sub>\u2010weighted MR images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Reviewers blinded to genotype independently measured seminal vesicle lumen diameter and prevalence of cysts in prostate, kidney, and liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Nonparametric tests for group comparisons and univariate and multivariable logistic regression analyses to identify associations of megavesicles and prostate median cysts with mutations and renal\/hepatic cyst burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seminal megavesicles were found in 23 of 92 ADPKD (25%) subjects with <jats:italic>PKD1<\/jats:italic> (22\/71, 31%) or <jats:italic>PKD2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20091\/21, 5%) mutations, but in only two control subjects (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Prostate median cysts were found in 17\/92 (18%) ADPKD subjects, compared with only 6\/92 (7%) controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), and were correlated with seminal vesicle diameters (\u03c1\u2009=\u20090.24, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Nonmedian prostate cyst prevalence was identical between ADPKD and controls (7\/92, 8%). After adjusting for age, estimated glomerular filtration rate, and height\u2010adjusted total kidney volume, ADPKD subjects with megavesicles were 10 times more likely to have a <jats:italic>PKD1<\/jats:italic> than a <jats:italic>PKD2<\/jats:italic> mutation. Among PKD1 subjects, seminal megavesicles occurred more frequently with nontruncating mutations with less severe kidney involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>ADPKD is associated with prostate median cysts near ejaculatory ducts. These cysts correlate with seminal megavesicles (dilated to &gt;10\u2009mm) which predict a 10\u2010fold greater likelihood of <jats:italic>PKD1<\/jats:italic> vs. <jats:italic>PKD2<\/jats:italic> mutation. Cysts elsewhere in the prostate are not related to ADPKD.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;49:894\u2013903.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26289","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T10:07:48Z","timestamp":1537351668000},"page":"894-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease"],"prefix":"10.1002","volume":"49","author":[{"given":"Weiguo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea J.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon 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