{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T07:34:27Z","timestamp":1775374467866,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T00:00:00Z","timestamp":1544832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Contrast\u2010enhanced magnetic resonance imaging (CE\u2010MRI) of the breast is highly sensitive for breast cancer detection. Multichannel coils and 3T scanners can increase signal, spatial, and temporal resolution. In addition, the T<jats:sub>1<\/jats:sub>\u2010reduction effect of a gadolinium\u2010based contrast agent (GBCA) is higher at 3T. Thus, it might be possible to reduce the dose of GBCA at 3T without losing diagnostic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare a three\u2010quarter (0.075 mmol\/kg) dose of the high\u2010relaxivity GBCA gadobenate dimeglumine, with a 1.5\u2010fold higher than on\u2010label dose (0.15 mmol\/kg) of gadoterate meglumine for breast lesion detection and characterization at 3T CE\u2010MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective, randomized, intraindividual comparative study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eligible were patients with imaging abnormalities (BI\u2010RADS 0, 4, 5) on conventional imaging. Each patient underwent two examinations, 24\u201372 hours apart, one with 0.075 mmol\/kg gadobenate and the other with 0.15 mmol\/kg gadoterate administered in a randomized order. In all, 109 patients were prospectively recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T MRI with a standard breast protocol (dynamic\u2010CE, T<jats:sub>2<\/jats:sub>w\u2010TSE, STIR\u2010T<jats:sub>2<\/jats:sub>w, DWI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Histopathology was the standard of reference. Three blinded, off\u2010site breast radiologists evaluated the examinations using the BI\u2010RADS lexicon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Lesion detection, sensitivity, specificity, and diagnostic accuracy were calculated per\u2010lesion and per\u2010region, and compared by univariate and multivariate analysis (Generalized Estimating Equations, GEE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients were excluded, leaving 104 women with 142 histologically verified breast lesions (109 malignant, 33 benign) available for evaluation. Lesion detection with gadobenate (84.5\u201088.7%) was not inferior to gadoterate (84.5\u201390.8%) (<jats:italic>P<\/jats:italic> \u2265 0.165). At per\u2010region analysis, gadobenate demonstrated higher specificity (96.4\u201398.7% vs. 92.6\u201397.3%, <jats:italic>P<\/jats:italic> \u2264 0.007) and accuracy (96.3\u201397.8% vs. 93.6\u201396.1%, <jats:italic>P<\/jats:italic> \u2264 0.001) compared with gadoterate. Multivariate analysis demonstrated superior, reader\u2010independent diagnostic accuracy with gadobenate (odds ratio\u2009=\u20091.7, <jats:italic>P<\/jats:italic> &lt; 0.001 using GEE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>A 0.075 mmol\/kg dose of the high\u2010relaxivity contrast agent gadobenate was not inferior to a 0.15 mmol\/kg dose of gadoterate for breast lesion detection. Gadobenate allowed increased specificity and accuracy.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;49:1157\u20131165.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26335","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T15:34:09Z","timestamp":1544888049000},"page":"1157-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Breast lesion detection and characterization with contrast\u2010enhanced magnetic resonance imaging: Prospective randomized intraindividual comparison of gadoterate meglumine (0.15 mmol\/kg) and gadobenate dimeglumine (0.075 mmol\/kg) at 3T"],"prefix":"10.1002","volume":"49","author":[{"given":"Paola","family":"Clauser","sequence":"first","affiliation":[{"name":"Department of Biomedical Imaging and Image\u2010guided Therapy, Division of Molecular and Gender Imaging Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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