{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:57:26Z","timestamp":1760014646721,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1532107","81771789"],"award-info":[{"award-number":["U1532107","81771789"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Accurate and complete response evaluation after treatment is important to implement individualized therapy for gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the effectiveness of diffusion kurtosis imaging (DKI) and in\u2010line X\u2010ray phase contrast imaging (ILXPCI) in the assessment of the therapeutic efficacy by transforming growth factor beta 1 (TGF\u2010\u03b21) inhibition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Model<\/jats:title><jats:p>Thirty nude mice subcutaneous xenotransplantation tumor model of gastric cancer for DKI and 10 peritoneal metastasis nude mice model for ILXPCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Examinations before and serially at 7, 14, 21, and 28 days after TGF\u2010\u03b21 inhibition treatment were performed at 3T MRI including T<jats:sub>2<\/jats:sub>\u2010weighted imaging (T<jats:sub>2<\/jats:sub>WI) and DKI with five <jats:italic>b<\/jats:italic> values of 0, 500, 1000, 1500, 2000 s\/mm<jats:sup>2<\/jats:sup>; ILXPCI examinations were performed at 14 days after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>DKI parameters (apparent diffusion coefficient [ADC], diffusivity [D] and kurtosis [K]) were calculated by two experienced radiologists after postprocessing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>For the differences in all the parameters between the baseline and each timepoint for both the treated and the control mice, the Mann\u2013Whitney test was used. The Spearman correlation test was used to evaluate correlations among the DKI parameters and corresponding pathologic necrosis fraction (NF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ADC, D, and K values were significantly different between the two groups after treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Serial measurements in the treated group showed that the ADC, D, and K values were significantly different at 7, 14, 21, and 28 days compared with baseline (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There were significant correlations between DKI parameters and NF (ADC, <jats:italic>r<\/jats:italic>\u2009=\u20090.865, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; D, <jats:italic>r<\/jats:italic>\u2009=\u20090.802, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; K, <jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.944, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The ILXPCI results in the treated group showed a stronger absorption area than the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>DKI may be used to evaluate the complete course therapeutic effects of gastric cancer induced by TGF\u2010\u03b21 inhibition, and the ILXPCI technique will improve the tumor microstructure resolution.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 4<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;49:1553\u20131564.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26523","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T11:07:25Z","timestamp":1538824045000},"page":"1553-1564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Effects of TGF\u2010\u03b21 Inhibition on Gastric Cancer in Nude Mice by Diffusion Kurtosis Imaging and In\u2010Line X\u2010ray Phase Contrast Imaging With Sequential Histology"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-9547","authenticated-orcid":false,"given":"Bowen","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pathology, RuiJin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilai","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibo","family":"Chen","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Ren","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Applied Physics, Chinese Academy of Sciences  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1477-3163.146506"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.01.029"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18422"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.07.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0019-3"},{"key":"e_1_2_7_10_1","first-page":"212","article-title":"Gastric carcinoma: imaging diagnosis, staging and assessment of treatment response","volume":"13","author":"Hallinan JT","year":"2013","journal-title":"Cancer Res"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-32-93"},{"key":"e_1_2_7_12_1","first-page":"269","article-title":"The role of diffusion weighted magnetic resonance imaging in oncologic settings","volume":"3","author":"Bozgeyik Z","year":"2013","journal-title":"Quant Imaging Med Surg"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5030875"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20508"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12110927"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112290"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3146-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15141625"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24910"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.130"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1146073"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/384335a0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4440-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24277"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"e0138702","DOI":"10.1371\/journal.pone.0138702","article-title":"Diffusion\u2010weighted imaging in 3.0 Tesla breast MRI: Diagnostic performance and tumor characterization using small subregions vs. whole tumor regions of interest","volume":"10","author":"Arponen O","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24989"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2016.17.5.650"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131165"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2014.08.009"},{"key":"e_1_2_7_32_1","first-page":"4479","article-title":"Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor\u2010beta signaling pathway","volume":"9","author":"Herbertz S","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02292.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142463"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120167"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110577"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087024"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2012.9047"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2483071407"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2012.03.002"},{"key":"e_1_2_7_41_1","first-page":"115","article-title":"Tumour morphology after neoadjuvant chemotherapy as a predictor of survival in serous ovarian cancer: an experience from a tertiary care centre in India","volume":"37","author":"Khandakar B","year":"2015","journal-title":"Malays J Pathol"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.26523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.26523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T04:34:03Z","timestamp":1693542843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.26523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jmri.26523"],"URL":"https:\/\/doi.org\/10.1002\/jmri.26523","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"type":"print","value":"1053-1807"},{"type":"electronic","value":"1522-2586"}],"subject":[],"published":{"date-parts":[[2018,10,6]]},"assertion":[{"value":"2018-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}