{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:10:57Z","timestamp":1790730657119,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011074","name":"Universit\u00e9 de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Overweight and obesity are major worldwide health concerns characterized by an abnormal accumulation of fat in adipose tissue (AT) and liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the volume and the fatty acid (FA) composition of the subcutaneous adipose tissue (SAT) and the visceral adipose tissue (VAT) and the fat content in the liver from 3D chemical\u2010shift\u2010encoded (CSE)\u2010MRI acquisition, before and after a 31\u2010day overfeeding protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective and longitudinal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Twenty\u2010one nonobese healthy male volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3D spoiled\u2010gradient multiple echo sequence and STEAM sequence were performed at 3T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>AT volume was automatically segmented on CSE\u2010MRI between L2 to L4 lumbar vertebrae and compared to the dual\u2010energy X\u2010ray absorptiometry (DEXA) measurement. CSE\u2010MRI and MR spectroscopy (MRS) data were analyzed to assess the proton density fat fraction (PDFF) in the liver and the FA composition in SAT and VAT. Gas chromatography\u2010mass spectrometry (GC\u2010MS) analyses were performed on 13 SAT samples as a FA composition countermeasure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Paired <jats:italic>t<\/jats:italic>\u2010test, Pearson's correlation coefficient, and Bland\u2013Altman plots were used to compare measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SAT and VAT volumes significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). CSE\u2010MRI and DEXA measurements were strongly correlated (<jats:italic>r<\/jats:italic>\u2009=\u20090.98, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). PDFF significantly increased in the liver (+1.35, <jats:italic>P<\/jats:italic>\u2009=\u20090.002 for CSE\u2010MRI,\u2009+\u20091.74, <jats:italic>P<\/jats:italic>\u2009=\u20090.002 for MRS). FA composition of SAT and VAT appeared to be consistent between localized\u2010MRS and CSE\u2010MRI (on whole segmented volume) measurements. A significant difference between SAT and VAT FA composition was found (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for CSE\u2010MRI, <jats:italic>P<\/jats:italic>\u2009=\u20090.001 for MRS). MRS and CSE\u2010MRI measurements of the FA composition were correlated with the GC\u2010MS results (for <jats:italic>ndb<\/jats:italic>: r<jats:sub>MRS\/GC\u2010MS<\/jats:sub>\u2009=\u20090.83 <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, r<jats:sub>CSE\u2010MRI\/GC\u2010MS<\/jats:sub>\u2009=\u20090.84, <jats:italic>P<\/jats:italic>\u2009=\u20090.001; for <jats:italic>nmidb<\/jats:italic>: r<jats:sub>MRS\/GC\u2010MS<\/jats:sub>\u2009=\u20090.74, <jats:italic>P<\/jats:italic>\u2009=\u20090.006, r<jats:sub>CSE\u2010MRI\/GC\u2010MS<\/jats:sub>\u2009=\u20090.66, <jats:italic>P<\/jats:italic>\u2009=\u20090.020)<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The follow\u2010up of liver PDFF, volume, and FA composition of AT during an overfeeding diet was demonstrated through different methods. The CSE\u2010MRI sequence associated with a dedicated postprocessing was found reliable for such quantification.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;49:1587\u20131599.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26532","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T05:35:25Z","timestamp":1539754525000},"page":"1587-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["3D Chemical Shift\u2010Encoded MRI for Volume and Composition Quantification of Abdominal Adipose Tissue During an Overfeeding Protocol in Healthy Volunteers"],"prefix":"10.1002","volume":"49","author":[{"given":"Angeline","family":"Nemeth","sequence":"first","affiliation":[{"name":"Univ Lyon, INSA\u2010Lyon, Universit\u00e9 Claude Bernard Lyon 1, UJM\u2010Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206  F69621 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9r\u00e9nice","family":"Segrestin","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Nutrition Humaine Rh\u00f4ne\u2010Alpes 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