{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:35:39Z","timestamp":1791599739615,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["No. 7172064\/No. 7162048\/No. 7182044"],"award-info":[{"award-number":["No. 7172064\/No. 7162048\/No. 7182044"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.61527807\/No.81701644\/No.61801311"],"award-info":[{"award-number":["No.61527807\/No.81701644\/No.61801311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There have been recent efforts to characterize brain functional activity features in patients with pulsatile tinnitus (PT). These efforts have revealed evidence of aberrant functional connectivity (FC) of the right middle temporal gyrus (MTG) in PT patients with prolonged disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the possible predictive effect of aberrant FC of MTG in PT patients with prolonged disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Thirty\u2010four patients with recent\u2010onset PT (RPTIN), 24 patients with long\u2010term PT (LPTIN), and 35 age\u2010, gender\u2010, and education\u2010matched healthy controls were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T MRI system and echo\u2010planar imaging (EPI) sequence, 3D brain volume imaging (BRAVO) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Functional MRI data preprocessing was performed in Data Processing &amp; Analysis for Brain Imaging (DPABI) and Statistical Parametric Mapping (SPM) 8. The FC analyses were conducted using the software REST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>One\u2010way analysis of covariance was conducted between three groups with age and gender as covariates, and post\u2010hoc analysis was used to identify the sources of group effects. Pearson's correlation analysis was conducted for the z\u2010values of altered FC strength in the PT group and the clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among hubs belonging to the executive control network, the default mode network (DMN), and limbic network, the strength of FC was mainly decreased in the patient groups compared with normal controls (<jats:italic>P<\/jats:italic> &lt; 0.05). Relative to RPTIN patients and normal controls, LPTIN patients were further characterized by significantly decreased FC between several short\u2010range brain regions adjacent to the seed (<jats:italic>P<\/jats:italic> &lt; 0.05). Finally, disease duration was negatively correlated with decreased FC between the seed and right fusiform gyrus\/parahippocampal gyrus, right inferior frontal gyrus, and right MTG (a brain area adjacent to the seed region).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Long\u2010term reactions to PT mainly involved weakened short\u2010range FC, especially within a functional network in the right temporal lobe.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 4<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26545","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T16:09:01Z","timestamp":1545408541000},"page":"1629-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010term reactions to pulsatile tinnitus are marked by weakened short\u2010range functional connectivity within a brain network in the right temporal lobe"],"prefix":"10.1002","volume":"49","author":[{"given":"Wang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Pengfei","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Heyu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Hongxia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yawen","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Beihang University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhengyu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Shusheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Friendship Hospital, Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhenghan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhenchang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60142-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshd.5503.439"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25010"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813520291"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5277"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.151648"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.08.014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.09.020"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.01.013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24080"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.03.021"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036222"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.029"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-013-0295-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.09.011"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1506631"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000366110.87836.53"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.127712"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-11"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6189-4"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.11.JNS10197"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3827-8"},{"key":"e_1_2_5_26_1","first-page":"1635","article-title":"CT arteriography and venography in pulsatile tinnitus: preliminary results","volume":"27","author":"Krishnan A","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31816569c4"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068910"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.04.024"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800454503"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/161478"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001414107"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-11"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15574-4"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.10.039"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.01.013"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.015"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.81"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09040456"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21426"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.26545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.26545","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T04:34:05Z","timestamp":1693542845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.26545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jmri.26545"],"URL":"https:\/\/doi.org\/10.1002\/jmri.26545","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,21]]},"assertion":[{"value":"2018-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}