{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:54:08Z","timestamp":1760014448354},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371516","81501441","81671751"],"award-info":[{"award-number":["81371516","81501441","81671751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Conventional MRI is limited in quantitative evaluation of ankylosing spondylitis (AS) activity states. A comparison of the effectiveness of the whole\u2010lesion apparent diffusion coefficient (ADC) histogram analysis with the Spondyloarthritis Research Consortium of Canada (SPARCC) MRI index in evaluating the disease activity of AS might aid in this assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the effectiveness of the whole\u2010lesion ADC histogram analysis with the SPARCC MRI index in evaluating the disease activity states of AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 57 AS patients and 27 healthy matched volunteers were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T MR including a diffusion\u2010weighted imaging (DWI) sequence (b\u2009=\u20090, 1000 s\/mm<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>One\u2010way analysis of variance (ANOVA) and Scheffe's post\u2010hoc was used to compare the parameters among different groups. A receiver operating characteristic (ROC) analysis and the Spearman rank correlation were performed to test the diagnostic performance of all parameters in distinguishing different disease activity states and determining the correlations between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>AS disease activity states was evaluated according to the Ankylosing Spondylitis Disease Activity Score (ASDAS). Initial DWI images and corresponding ADC maps were imported into our in\u2010house software. Regions of interest (ROIs) were drawn in all slices and the relevant parameters were derived simultaneously. The SPARCC MRI index scores were counted artificially based on T<jats:sub>2<\/jats:sub>\u2010PDW\u2010SPAIR images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ADC<jats:sub>mean<\/jats:sub>, ADC percentiles, and SPARCC MRI index of the active group were significantly higher than the inactive and control groups (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The 90th percentile could differentiate the inactive from the control group and the low disease activity group from the inactive group (<jats:italic>P<\/jats:italic>\u2009=\u20090.011 and 0.006, respectively). The 50th percentile of the high disease activity group was significantly higher than the low group (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), while the SPARCC MRI index of the very high disease activity group was higher than the high group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The whole\u2010volume ADC histogram analysis was superior to the SPARCC MRI index in assessing AS activity states.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:114\u2013126.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26568","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T06:04:14Z","timestamp":1545026654000},"page":"114-126","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Whole\u2010lesion ADC histogram analysis and the spondyloarthritis research consortium of canada (SPARCC) MRI index in evaluating the disease activity of ankylosing spondylitis"],"prefix":"10.1002","volume":"50","author":[{"given":"Fengxian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibo","family":"Chen","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School  Nanjing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"742","article-title":"Ankylosing spondylitis and uveitis: Overview","volume":"525","author":"Gouveia EB","year":"2012","journal-title":"Rev Brasil Reumatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.892529"},{"key":"e_1_2_6_4_1","first-page":"234","article-title":"Magnetic resonance imaging of sacroiliitis in early seronegative spondylarthropathy. 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