{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:03:22Z","timestamp":1778126602296,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771911"],"award-info":[{"award-number":["81771911"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301210"],"award-info":[{"award-number":["81301210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601459"],"award-info":[{"award-number":["81601459"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) can noninvasively estimate the perfusion and function of the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the perfusion and functional status using rs\u2010fMRI in acute ischemic stroke (AIS) patients after reperfusion therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Twenty\u2010five AIS patients who underwent dynamic susceptibility contrast (DSC) upon hospital admission and both rs\u2010fMRI and DSC scans at 24 hours after reperfusion therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T; DSC, rs\u2010fMRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The time delay of the blood oxygenation level\u2010dependent (BOLD) signal was calculated using time\u2010shift\u2010analysis (TSA) and compared with the time to peak (TTP) derived from the DSC. For patients who exhibited partial or complete reperfusion in the supratentorial hemisphere, we quantified the function of different regions (healthy tissue, reperfused tissue, not reperfused tissue) by using three rs\u2010fMRI measurements (functional connectivity, the amplitude of low\u2010frequency fluctuation [ALFF] and regional homogeneity [ReHo]). Correlations between the functional measurements and modified Rankin Scale (mRS) scores were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Dice coefficient (DC) analysis, two\u2010sample <jats:italic>t<\/jats:italic>\u2010tests, Pearson correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients who exhibited complete reperfusion on their TTP maps showed no time\u2010delayed areas on the TSA maps. For the remaining 13 patients with partial reperfusion (5\/13) or no reperfusion (8\/13) on the TTP maps, the TSA detected comparable time\u2010delayed areas. Eleven out of 13 patients showed moderate to good overlap (mean DC, 0.58\u2009\u00b1\u20090.1) between the TTP and TSA results. Fourteen patients were chosen for functional analyses and most patients (12\/14) showed abnormal functional connectivity in the reperfused regions. The reperfused and not reperfused tissues had lower mean ReHo values than those of the healthy tissue (both <jats:italic>P<\/jats:italic> &lt; 0.001). The mRS scores showed negative correlation with mean ReHo values of reperfused region (<jats:italic>R<\/jats:italic>\u2009=\u2009\u20130.523, <jats:italic>P<\/jats:italic>\u2009=\u20090.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>rs\u2010fMRI might be a useful way to estimate both the perfusion and functional status for AIS patients after reperfusion therapy.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:221\u2013229.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26571","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T06:24:15Z","timestamp":1545287055000},"page":"221-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["One\u2010step analysis of brain perfusion and function for acute stroke patients after reperfusion: A resting\u2010state fMRI study"],"prefix":"10.1002","volume":"50","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junshan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Jiangning Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cunnan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizheng","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of MR Clinical Science  Philips Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingdong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"Lv","sequence":"additional","affiliation":[{"name":"Institutes of Psychological Sciences Hangzhou Normal University  Hangzhou Zhejiang China"},{"name":"Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000074"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13767"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000371"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009160"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000135"},{"key":"e_1_2_5_7_1","first-page":"161595","article-title":"Gadolinium deposition in human brain tissues after contrast\u2010enhanced MR imaging in adult patients without intracranial abnormalities","author":"McDonald RJ","year":"2017","journal-title":"Radiology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.346"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016150789"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199703000-00007"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23763"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41586"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130982"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13377"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21227"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx169"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044556"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105117"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000086"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01655"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.11.2220"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015566"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4868-y"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.80"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24614"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011641"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22711"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1439-12.2012"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.645614"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.26571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.26571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:33:20Z","timestamp":1694352800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.26571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/jmri.26571"],"URL":"https:\/\/doi.org\/10.1002\/jmri.26571","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]},"assertion":[{"value":"2018-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}