{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:59:26Z","timestamp":1788962366619,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteonecrosis of the lunate, Kienb\u00f6ck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienb\u00f6ck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast\u2010enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the use of DCE\u2010MR for assessing perfusion in the lunate bone in patients with Kienb\u00f6ck's disease. Furthermore, to compare perfusion with histopathology with a focus on bone viability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Fourteen patients with Kienb\u00f6ck's disease and a control group of 19 healthy subjects.<\/jats:p>\n                    <jats:p>\n                      Field Strength: 3 T with T\n                      <jats:sub>1<\/jats:sub>\n                      \u2010weighted fat\u2010saturated contrast\u2010enhanced gradient echo series.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Features of the enhancement curves from the DCE\u2010MR examinations, time to peak (TTP), maximum slope (MS), and maximum enhancement (ME) assessed by a radiologist. Six of 14 patients were surgerized with lunate excision, allowing comparison between features of the enhancement curves and histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test.\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05 was considered a statistically significant difference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with Kienb\u00f6ck's disease showed significantly higher and faster perfusion parameters compared with the control group, the mean value of the TTP in patients was 126.73 sec, in controls 189.79 sec (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.024), ME in patients 173.55 AU, in controls 28.46 AU (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), and MS in patients 5.04 AU, in controls 1.06 AU (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). When compared with histopathology, increased perfusion was seen in areas of bone formation but also in necrosis. Areas of normal bone showed low perfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>DCE\u2010MRI at 3 T can diagnose altered perfusion in patients with Kienb\u00f6ck's disease. Increased perfusion cannot definitely be used as a marker of bone viability.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Level of Evidence<\/jats:bold>\n                      : 1\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Technical Efficacy<\/jats:bold>\n                      : Stage 3\n                    <\/jats:p>\n                    <jats:p>J. Magn. Reson. Imaging 2019;50:481\u2013489.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.26573","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:42:40Z","timestamp":1545007360000},"page":"481-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased perfusion in dynamic gadolinium\u2010enhanced MRI correlates with areas of bone repair and of bone necrosis in patients with Kienb\u00f6ck's disease"],"prefix":"10.1002","volume":"50","author":[{"given":"Gunilla","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Radiology Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-5142","authenticated-orcid":false,"given":"Sven","family":"M\u00e5nsson","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Physics Lund University Malm\u00f6 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