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A secondary goal was to compare the imaging appearance of knee abnormalities depicted with 5\u2010minute DESS paired with a 2\u2010minute coronal proton\u2010density fat\u2010saturated (PDFS) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Thirty\u2010six consecutive patients (19 male) referred for a routine knee MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequences<\/jats:title><jats:p>DESS and PDFS at 3T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Five musculoskeletal radiologists evaluated all images for the presence of internal knee derangement using DESS, DESS+PDFS, and the conventional imaging protocol, and their associated diagnostic confidence of the reading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Differences in positive and negative percent agreement (PPA and NPA, respectively) and 95% confidence intervals (CIs) for DESS and DESS+PDFS compared with the conventional protocol were calculated and tested using exact McNemar tests. The percentage of observations where DESS or DESS+PDFS had equivalent confidence ratings to DESS+Conv were tested with exact symmetry tests. Interreader agreement was calculated using Krippendorff's alpha.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DESS had a PPA of 90% (88\u201392% CI) and NPA of 99% (99\u201399% CI). DESS+PDFS had increased PPA of 99% (95\u201399% CI) and NPA of 100% (99\u2013100% CI) compared with DESS (both <jats:italic>P<\/jats:italic> &lt; 0.001). DESS had equivalent diagnostic confidence to DESS+Conv in 94% of findings, whereas DESS+PDFS had equivalent diagnostic confidence in 99% of findings (both <jats:italic>P<\/jats:italic> &lt; 0.001). All readers had moderate concordance for all three protocols (Krippendorff's alpha 47\u201348%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Both 1) 5\u2010minute 3D\u2010DESS with separated echoes and 2) 5\u2010minute 3D\u2010DESS paired with a 2\u2010minute coronal PDFS sequence depicted knee abnormalities similarly to a routine clinical knee MRI protocol, which may be a promising technique for abbreviated knee MRI.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26582","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T06:18:54Z","timestamp":1545632334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Combined 5\u2010minute double\u2010echo in steady\u2010state with separated echoes and 2\u2010minute proton\u2010density\u2010weighted 2D FSE sequence for comprehensive whole\u2010joint knee MRI assessment"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-6796","authenticated-orcid":false,"given":"Akshay S.","family":"Chaudhari","sequence":"first","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"},{"name":"Department of Bioengineering Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"},{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bragi","family":"Sveinsson","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"},{"name":"Athinoula A. 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