{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:24:25Z","timestamp":1785799465571,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The identification of hypoxia inducible factor (HIF\u20101\u03b1) expression is helpful for the quantitative assessment of tumor hypoxia. The application of multimodal imaging techniques may play a part in the assessment of HIF\u20101\u03b1 expression of cervical carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the correlations between multiple imaging parameters and HIF\u20101\u03b1 expression of early cervical carcinoma and to determine whether tumor hypoxia can be predicted using multisequence imaging parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective observational.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>One hundred patients with early cervical carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequences<\/jats:title><jats:p>3.0 T MRI including intravoxel incoherent motion (IVIM) diffusion\u2010weighted imaging (DWI) and dynamic contrast\u2010enhanced (DCE) perfusion MRI sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>DCE\u2010MRI and IVIM DWI were performed for all patients. The imaging parameters included volume transfer constant (K<jats:sup>trans<\/jats:sup>), rate constant (K<jats:sub>ep<\/jats:sub>), extravascular extracellular volume fraction (V<jats:sub>e<\/jats:sub>), D, D*, and f.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The comparisons of imaging parameters between two independent groups were performed using the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test. Multiple linear regression analysis was performed to determine the correlation between multiple imaging parameters and HIF\u20101\u03b1 expression. The diagnostic ability of DCE\u2010MRI, IVIM DWI, and the combination of two techniques for discriminating high\u2010expression and low\u2010expression groups were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high\u2010expression group had a lower K<jats:sup>trans<\/jats:sup> or K<jats:sub>ep<\/jats:sub> value than the low\u2010expression group (<jats:italic>P<\/jats:italic> = 0.03; 0.02), while the high\u2010expression group had a higher V<jats:sub>e<\/jats:sub> value than the low\u2010expression group (<jats:italic>P<\/jats:italic> = 0.03). The high\u2010expression group had a higher D or f value than the low\u2010expression group (<jats:italic>P<\/jats:italic> = 0.02; 0.02). K<jats:sup>trans<\/jats:sup>, K<jats:sub>ep<\/jats:sub>, D, V<jats:sub>e<\/jats:sub>, and f values were independently correlated with HIF\u20101\u03b1 expression. The sensitivity or accuracy of a combined method was higher than that of DCE\u2010MRI or IVIM DWI individually (<jats:italic>P<\/jats:italic> = 0.03, 0.02; 0.04, 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The combination of DCE\u2010MRI and IVIM DWI can improve the diagnostic ability of discriminating different HIF\u20101\u03b1 expression levels for early cervical tumors.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage<\/jats:bold>: 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:918\u2013929.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26604","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T11:26:10Z","timestamp":1547637970000},"page":"918-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Intravoxel Incoherent Motion Combined With Dynamic Contrast\u2010Enhanced Perfusion MRI of Early Cervical Carcinoma: Correlations Between Multimodal Parameters and HIF\u20101\u03b1 Expression"],"prefix":"10.1002","volume":"50","author":[{"given":"Xiangsheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology Air Force General Hospital, People's Liberation Army  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shandong","family":"Wu","sequence":"additional","affiliation":[{"name":"Imaging Research Division Department of Radiology, Biomedical Informatics, and Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Air Force General Hospital, People's Liberation Army  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Cancer Hospital of China Medical University; Liaoning Cancer Hospital &amp; Institute  Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Air Force General Hospital, People's Liberation Army  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology Air Force General Hospital, People's Liberation Army  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