{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:19:37Z","timestamp":1769188777838,"version":"3.49.0"},"reference-count":161,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>There are serious clinical gaps in our understanding of chronic lung disease that require novel, sensitive, and noninvasive in vivo measurements of the lung parenchyma to measure disease pathogenesis and progressive changes over time as well as response to treatment. Until recently, our knowledge and appreciation of the tissue changes that accompany lung disease has depended on ex vivo biopsy and concomitant histological and stereological measurements. These measurements have revealed the underlying pathologies that drive lung disease and have provided important observations about airway occlusion, obliteration of the terminal bronchioles and airspace enlargement, or fibrosis and their roles in disease initiation and progression. ex vivo tissue stereology and histology are the established gold standards and, more recently, micro\u2010computed tomography (CT) measurements of ex vivo tissue samples has also been employed to reveal new mechanistic findings about the progression of obstructive lung disease in patients. While these approaches have provided important understandings using ex vivo analysis of excised samples, recently developed hyperpolarized noble gas MRI methods provide an opportunity to noninvasively measure acinar duct and terminal airway dimensions and geometry in vivo, and, without radiation burden. Therefore, in this review we summarize emerging pulmonary MRI morphometry methods that provide noninvasive in vivo measurements of the lung in patients with bronchopulmonary dysplasia and chronic obstructive pulmonary disease, among others. We discuss new findings, future research directions, as well as clinical opportunities to address current gaps in patient care and for testing of new therapies.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 5<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 5<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:28\u201340.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26623","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T04:30:57Z","timestamp":1547440257000},"page":"28-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications"],"prefix":"10.1002","volume":"50","author":[{"given":"Andrew","family":"Westcott","sequence":"first","affiliation":[{"name":"Robarts Research Institute University of Western Ontario  London Canada"},{"name":"Department of Medical Biophysics University of Western Ontario  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"McCormack","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine University of Western Ontario  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Parraga","sequence":"additional","affiliation":[{"name":"Robarts Research Institute University of Western Ontario  London Canada"},{"name":"Department of Medical Biophysics University of Western Ontario  London Canada"},{"name":"Division of Respirology, Department of Medicine University of Western Ontario  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei","family":"Ouriadov","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Western Ontario  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0025727300039004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196806202782501"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106955"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-090OC"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9906011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015141579"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.12.3.219"},{"key":"e_1_2_9_9_1","first-page":"131","article-title":"Principles and methods for the morphometric study of the lung and other organs","volume":"12","author":"Weibel ER","year":"1963","journal-title":"Lab Invest"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1107OC"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01587.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00429.2012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19960815)34:6<556::AID-JEMT8>3.0.CO;2-H"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1998.tb01395.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.58.030196.000445"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1982.tb00376.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198003000-00010"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.20.003880"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597038"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/14\/3\/006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91227.2008"},{"key":"e_1_2_9_22_1","first-page":"359","article-title":"Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro\u2010computed tomography","volume":"23","author":"Akhavan Sharif MR","year":"2010","journal-title":"NMR Biomed"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00009.2007"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00629.2006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2013007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00088.2005"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2363041142"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21161"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201602-0278OC"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7799(02)02004-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200508-080DS"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1522ST"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/126.1.125"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1148\/129.2.521"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(82)80301-2"},{"key":"e_1_2_9_36_1","first-page":"541","article-title":"The diagnosis of emphysema. A computed tomographic\u2010pathologic correlation","volume":"133","author":"Bergin C","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.159.1.3952318"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.1.3336706"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.176.1.2353097"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0272-5231(21)00926-6","article-title":"Imaging of small airways diseases","volume":"14","author":"Lynch DA","year":"1993","journal-title":"Clin Chest Med"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.3.730"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1437-z"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200111000-00004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.8829"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9805067"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25010"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.303095101"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/370199a0"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.21.11478"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200008)44:2<174::AID-MRM2>3.0.CO;2-4"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000262571.81771.66"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070314"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22697"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052594699"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26642"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20300"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.04.013"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12068"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199910)42:4<721::AID-MRM14>3.0.CO;2-D"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2221001834"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00397.2006"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2004.08.002"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2393050111"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00185.2005"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21212"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2011.10.007"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25241"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24595"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25550"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0332MA"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203983"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1209904"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2013.09.019"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25825"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22375"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20876"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23844"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmra.1995.1055"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24950"},{"key":"e_1_2_9_80_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/978-3-642-87553-3","volume-title":"Morphometry of the human lung","author":"Weibel E.","year":"1963"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20070"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102226"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00386.2009"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2007.10.015"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphys.2005.04.006"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26279"},{"key":"e_1_2_9_87_1","unstructured":"ChanH\u2010F StewartN Parra\u2010RoblesJ CollierG WildJM. 3D mapping of whole lung morphometry with 129Xe diffusion\u2010weighted MRI and compressed sensing: comparison with 3He. In: ISMRM 25th Annual Meeting Honolulu; 2017:2138."},{"key":"e_1_2_9_88_1","unstructured":"AbascalJFPJ DescoM Parra\u2010RoblesJ. Incorporation of prior knowledge of the signal behavior into the reconstruction to accelerate the acquisition of MR diffusion data. ArXiv e\u2010prints [Internet].2017; 1702. Available from:http:\/\/adsabs.harvard.edu\/abs\/2017arXiv170202743A"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22737"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00736.2010"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25408"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23056"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803675-4.00012-9"},{"key":"e_1_2_9_94_1","first-page":"3(10)","article-title":"Noninvasive quantification of alveolar morphometry in elderly never\u2010 and ex\u2010smokers","author":"Paulin GA","year":"2015","journal-title":"Physiol Rep"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26960"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26120"},{"key":"e_1_2_9_97_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3941\/jrcr.v9i2.2048","article-title":"Pulmonary imaging abnormalities in an adult case of congenital lobar emphysema","volume":"9","author":"Pike D","year":"2015","journal-title":"J Radiol Case Rep."},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2017.05.008"},{"key":"e_1_2_9_99_1","unstructured":"LessardE OuriadovA PikeD McCormackDG ParragaG. Longitudinal three\u2010year decline in alpha\u20101 antitrypsin deficiency: regional worsening in emphysema and ventilation. American Thoracic Society Annual Scientific Meeting2016:A3141."},{"key":"e_1_2_9_100_1","unstructured":"RuppertK QuirkJD MuglerJPI et al. Lung morphometry using hyperpolarized xenon\u2010129: preliminary experience. In: ISMRM 20th Annual Meeting Melbourne [abstract];2012:1352."},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.12.010"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21076"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0000000000000244"},{"key":"e_1_2_9_104_1","unstructured":"LindenmaierA ZanetteB CouchM et al. Mapping lung microstructural changes using hyperpolarized 129Xe Morphometry in a rat model of bronchopulmonary dysplasia. ATS \u2014 What's New in Cystic Fibrosis BPD and Other Congenital Pediatric Lung Diseases.2018[Epub ahead of print]."},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/2331205X.2017.1282033"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.08.006"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02713907"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/34124307"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1950"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3263616"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.07.013"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2009.09.004"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2012.08.007"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.068"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4729713"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3642"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao3926"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00107514"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-2092-4"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10070"},{"key":"e_1_2_9_121_1","unstructured":"CallahanS FlorsL QingK et al. editors. Evaluation of hyperpolarized helium\u20103 imaging in transplant patients with BOS and RAS. ATS \u2014 Lung Transplant: Cellular and Physiological Investigations; San Diego.2018."},{"key":"e_1_2_9_122_1","unstructured":"SheaDA MorganD. The helium\u20103 shortage: supply demand and options for Congress. Tech Rep R41419.2010."},{"issue":"58","key":"e_1_2_9_123_1","article-title":"Feasibility of high quality lung MRI with naturally\u2010abundant hyperpolarised 129Xe","volume":"44","author":"Stewart NJ","year":"2014","journal-title":"Eur Respir J"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25732"},{"issue":"60","key":"e_1_2_9_125_1","article-title":"Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T","volume":"48","author":"Stewart N","year":"2016","journal-title":"Eur Respir J"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24111"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26279"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2513081550"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3730"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01206.2012"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25284"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22962"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2597"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3165"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25406"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130609"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199324000-00003"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027991"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24858"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23017"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24570"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3156"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22799"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22031"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.12.003"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-014-0432-9"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24236"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2017.04.012"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24680"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24764"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.08.018"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25503"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12944"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009124"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00089.2009"},{"key":"e_1_2_9_156_1","unstructured":"CharlesC JonesRW HalaweishAF AinslieMD. Parallel imaging for short breath hold times in perfluorinated gas imaging of the lung [abstract]. In: Proc 23rd Annual Meeting ISMRM Toronto;2015p 3984."},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370602"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012192"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25675"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00541.2015"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26574"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12886"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.26623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.26623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:34:11Z","timestamp":1694352851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.26623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,13]]},"references-count":161,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/jmri.26623"],"URL":"https:\/\/doi.org\/10.1002\/jmri.26623","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,13]]},"assertion":[{"value":"2018-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}