{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T10:43:34Z","timestamp":1768733014072,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Opioids are known to affect gastrointestinal motility, but their effect on fluid absorption and secretion is poorly understood in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the effect of oxycodone on colonic fecal volume and stool dryness by using a novel MRI\u2010based technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective, randomized, double\u2010blinded, crossover study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Twenty\u2010five healthy male volunteers (median age: 24 years [range: 21\u201356]; mean body mass index [BMI]: 23.9 kg\/m<jats:sup>2<\/jats:sup> [range: 22.9\u201325.0]) without known gastrointestinal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>T<jats:sub>2<\/jats:sub>\u2010weighted and two\u2010point Dixon MRI scans of the abdomen at 1.5 T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Subjects were treated for 5 days with prolonged\u2010release oxycodone or a placebo. Imaging was performed on the first and last study day in each period. Images of the colon were analyzed with semiautomatic k\u2010means\u2010based segmentation software. Regional colonic fecal volumes were quantified excluding gas volume and colon wall. Two\u2010point Dixon and T<jats:sub>2<\/jats:sub>\u2010weighted MRI signal intensity were assessed as a proxy of colonic stool dryness. Data were obtained in a previously reported study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Intraclass correlation coefficients were used to test the reliability of measurements between days, while repeated measures mixed models were applied to test treatment effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After oxycodone treatment, total colonic fecal volume was significantly increased compared with placebo (mean change 100 mL vs. \u201313 mL; <jats:italic>P<\/jats:italic> = 0.001), with the largest increase (24%) observed in the ascending colon\/cecum (<jats:italic>P<\/jats:italic> = 0.001). Dixon signal increased (less water in colon content) after oxycodone treatment compared with placebo (mean 0.09 vs. \u20130.02; <jats:italic>P<\/jats:italic> &lt; 0.001). T<jats:sub>2<\/jats:sub>\u2010weighted signal decreased (less water in colon content) after oxycodone treatment compared with placebo (mean \u20130.03 vs. 0.03; <jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The 5\u2010day oxycodone treatment increased colonic fecal volume and increased stool dryness compared with placebo. This imaging\u2010based method for noninvasive analysis of colon content has the potential to characterize gastrointestinal symptoms in general, such as in constipation.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage<\/jats:bold>: 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:733\u2013745.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26628","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T19:04:44Z","timestamp":1546628684000},"page":"733-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["MRI analysis of fecal volume and dryness: Validation study using an experimental oxycodone\u2010induced constipation model"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-7430","authenticated-orcid":false,"given":"Esben B.","family":"Mark","sequence":"first","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Mech\u2010Sense, Department of Radiology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg 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