{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:11:03Z","timestamp":1784891463882,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2242018k30004"],"award-info":[{"award-number":["2242018k30004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2242018\u2009k30004"],"award-info":[{"award-number":["2242018\u2009k30004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81520108015"],"award-info":[{"award-number":["81520108015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The thalamus is an integrative hub conveying sensory information between cortical areas and related to cognition. However, alterations of the thalamus following partial hearing deprivation remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the modifications of the thalamus and its seven subdivisions in terms of structure, function, and perfusion in subjects with sensorineural hearing loss (SNHL), as well as their associations with SNHL\u2010induced cognitive impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Thirty\u2010seven bilateral long\u2010term SNHL patients and 38 well\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength<\/jats:title><jats:p>3\u2009T\/BOLD, T<jats:sub>1<\/jats:sub>\u2010weighted imaging, arterial spin labeling (ASL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Quantitative measurements in the thalamus and subdivisions were obtained, including the relative volume, fractional amplitude of low\u2010frequency fluctuation (fALFF) within slow 5 (0.01\u20130.027\u2009Hz), slow 4 (0.027\u20130.073\u2009Hz), and combined frequency (0.01\u20130.073\u2009Hz), as well as the whole\u2010brain functional connectivity. Twenty\u2010five SNHL patients and 20 controls underwent ASL scanning. Then correlation analysis was computed between all significant changes and cognition tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Continuous and categorical variables were compared by independent\u2010sample <jats:italic>t<\/jats:italic>\u2010test and chi\u2010square test, respectively. Quantitative MRI measurement comparisons were corrected for multiple comparison, and functional connectivity (FC) analysis used two\u2010sample <jats:italic>t<\/jats:italic>\u2010test with false\u2010discovery rate correction. Area under the curve (AUC) in receiver operating characteristic curve analysis was applied to evaluate the power of alterations in differentiating SNHL and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference in the relative volume and perfusion of seven thalamus subdivisions were observed, but a decrease in fALFF in SNHL. SNHL showed reduced thalamic connectivity with the cerebellum lobule VIII, ventral anterior cingulate cortex, insula, superior temporal gyrus, media temporal gyrus, medial frontal gyrus, Heschl's gyrus, and temporal pole. And some FC abnormalities exhibited positive correlations with cognitive tests and high discriminative power (0.8\u2009&lt;\u2009AUC\u2009&lt;\u20091) in two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>SNHL led to decreased thalamic activity and widespread weakened connectivity with other brain areas.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage:<\/jats:bold> 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:787\u2013797.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26665","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T20:50:57Z","timestamp":1548795057000},"page":"787-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Sensorineural hearing loss and cognitive impairments: Contributions of thalamus using multiparametric MRI"],"prefix":"10.1002","volume":"50","author":[{"given":"Xiao\u2010Min","family":"Xu","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Jiao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School 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