{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:10:22Z","timestamp":1769551822599,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The dentate nuclei of the cerebellum are the areas where gadolinium predominantly accumulates. It is not yet known whether gadolinium deposition affects brain functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose\/Hypothesis<\/jats:title><jats:p>To assess whether gadolinium\u2010dependent high signal intensity of the cerebellum on T<jats:sub>1<\/jats:sub>\u2010weighted images of nonneurological adult patients with Crohn's disease is associated with modifications of resting\u2010state functional connectivity (RSFC) of the cerebellum and dentate nucleus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Observational, cross\u2010sectional.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fifteen patients affected by Crohn's disease were compared with 16 healthy age\u2010 and gender\u2010matched control subjects. All participants underwent neurological, neurocognitive\u2010psychological assessment, and blood sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5\u2010T magnet blood oxygenation level\u2010dependent (BOLD) functional MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>High signal intensity on T<jats:sub>1<\/jats:sub>\u2010weighted images, cerebellum functional connectivity, neurocognitive performance, and blood circulating gadolinium levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>An unpaired two\u2010sample <jats:italic>t<\/jats:italic>\u2010test (age and sex were nuisance variables) was used to investigate between\u2010group differences in cerebellar and dentate nucleus functional connectivity. Z\u2010statistical images were set using clusters determined by Z\u2009&gt;\u20092.3 and a familywise error (FWE)\u2010corrected cluster significance threshold of <jats:italic>P<\/jats:italic>\u2009=\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dentate nuclei RSFC was not different (<jats:italic>P<\/jats:italic>\u2009=\u2009n.s.) between patients with gadolinium\u2010dependent high signal intensity on T<jats:sub>1<\/jats:sub>\u2010weighted images and controls. Pre\u2010 and postcentral gyrus bilaterally and the right supplementary motor cortex showed a decrease of RSFC with the cerebellum hemispheres (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 FWE\u2010corrected) and was related to disease duration but not to gadodiamide cumulative doses (<jats:italic>P<\/jats:italic>\u2009=\u2009n.s.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Crohn's disease patients with gadolinium\u2010dependent hyperintense dentate nuclei on unenhanced T<jats:sub>1<\/jats:sub>\u2010weighted images do not show dentate nucleus RSFC changes.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage<\/jats:bold>: 5<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:445\u2013455.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26669","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T10:35:53Z","timestamp":1548412553000},"page":"445-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Absence of dentate nucleus resting\u2010state functional connectivity changes in nonneurological patients with gadolinium\u2010related hyperintensity on T<sub>1<\/sub>\u2010weighted images"],"prefix":"10.1002","volume":"50","author":[{"given":"Carlo A.","family":"Mallio","sequence":"first","affiliation":[{"name":"Departmental Faculty of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Piervincenzi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Neuroimaging Laboratory Universit\u00e0 La Sapienza  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Gianolio","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences Universit\u00e0 di Torino  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Cirimele","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi G.","family":"Papparella","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Marano","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Quintiliani","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"Aime","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences Universit\u00e0 di Torino  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Carducci","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Neuroimaging Laboratory Universit\u00e0 La Sapienza  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Parizel","sequence":"additional","affiliation":[{"name":"Department of Radiology Antwerp University Hospital  Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo C.","family":"Quattrocchi","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4378"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000072"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000154"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000431"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015150337"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016162241"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015150872"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4245-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15150025"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142690"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017161595"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003735"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000344"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5065-8"},{"key":"e_1_2_5_16_1","unstructured":"FDA warns that gadolinium\u2010based contrast agents (GBCAs) are retained in the body; Requires new class warnings. 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