{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:06:38Z","timestamp":1781139998566,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Management of adults with repaired congenital heart disease (CHD) is still challenging. Heart failure secondary to residual anatomical sequels or arrhythmic events is not rare in this population. MRI has emerged as an accurate tool to quantify pulmonary transit time (PTT) of intravenous contrast agents and pulmonary blood volume (PBV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the relationship between PTT, and conventional indexes of ventricular dysfunction and heart failure in a cohort of adults with CHD and to assess its association with adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>89 adult CHD patients (56 males, age 34\u2009\u00b1\u200911\u2009years) and 14 age\u2010 and sex\u2010matched healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>First\u2010pass perfusion and standard sequences for ventricular volumes and function and flow analysis at 1.5T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>PTT was calculated as the time required for a bolus of contrast agent to pass from the right ventricle to the left atrium, expressed both in seconds (PTTS) and number of heartbeats (PTTB). The pulmonary blood volume index (PBVI) was measured by the product of PTTB and the pulmonary artery stroke volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student's independent <jats:italic>t<\/jats:italic>\u2010test analysis of variance (ANOVA) and Mann\u2013Whitney nonparametric; Pearson's or Spearman's correlation; Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PTTS and PTTB were significantly higher in patients than in controls (7.6\u2009\u00b1\u20093 vs. 5.6\u2009\u00b1\u20091.2\u2009sec, <jats:italic>P<\/jats:italic>\u2009=\u20090.01 and 8\u2009\u00b1\u20093 vs. 6\u2009\u00b1\u20091\u2009bpm, <jats:italic>P<\/jats:italic>\u2009=\u20090.01, respectively). PTTS showed negative correlation with left ventricle ejection fraction (LVEF) and cardiac index (CI) (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.3, <jats:italic>P<\/jats:italic>\u2009=\u20090.004, and <jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.4, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively) as well as with left ventricle and atrial volumes. By Kaplan\u2013Meier survival analysis, PTTB &gt;8\u2009bpm was associated with significant increased risk of adverse outcome at mid\u2010term follow\u2010up. Moreover, patients with both increased PTTB and PBV have higher amino\u2010terminal portion of the prohormone brain natriuretic peptide (NT\u2010proBNP) and lower LVEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>PTT is prolonged in adult CHD in comparison with healthy subjects, likely reflecting reduced CI and ventricular dysfunction.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 3<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:779\u2013786.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26684","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T05:33:52Z","timestamp":1551850432000},"page":"779-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cardiac Magnetic Resonance Evaluation of Pulmonary Transit Time and Blood Volume in Adult Congenital Heart disease"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-5308","authenticated-orcid":false,"given":"Lamia","family":"Ait Ali","sequence":"first","affiliation":[{"name":"Institute of Clinical Physiology CNR  Massa Italy"},{"name":"MRI Lab, Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni D.","family":"Aquaro","sequence":"additional","affiliation":[{"name":"MRI Lab, Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Peritore","sequence":"additional","affiliation":[{"name":"Radiology Department A.R.N.A.S  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Ricci","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biomedical Technologies, Department of Neuroscience, Imaging and Clinical Sciences \"G. d'Annunzio\" University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"De Marchi","sequence":"additional","affiliation":[{"name":"MRI Lab, Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiovascular Medicine Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Passino","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiovascular Medicine Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Festa","sequence":"additional","affiliation":[{"name":"MRI Lab, Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"},{"name":"Pediatric Cardiology and GUCH Unit Fondazione G. 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