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The effect sizes (Cohen's <jats:italic>d<\/jats:italic>) of the mean differences were compared across regions and with previously published global data obtained with linear regression of the WM over the entire VOI in the same dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite patients' <jats:italic>global<\/jats:italic> VOI WM NAA being significantly lower than the controls', no <jats:italic>regional<\/jats:italic> differences were observed for any metabolite. Regional NAA comparisons, however, were <jats:italic>all<\/jats:italic> unidirectional (patients' NAA concentrations &lt; controls') within a narrow range: 0.3\u2009\u2264\u2009Cohen's <jats:italic>d<\/jats:italic>\u2009\u2264\u20090.6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Since the patient group was symptomatic and exhibiting global WM NAA deficits, these findings suggest: 1) diffuse axonal mTBI damage; that is 2) below the <jats:sup>1<\/jats:sup>H MRSI detection threshold in small regions. Therefore, larger, ie, more sensitive, single\u2010voxel <jats:sup>1<\/jats:sup>H MRS, placed anywhere in WM regions, may be well suited for mTBI <jats:sup>1<\/jats:sup>H MRS studies, given that these results are confirmed in other cohorts.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2019;50:1424\u20131432.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26718","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T04:44:57Z","timestamp":1552538697000},"page":"1424-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative multivoxel proton MR spectroscopy for the identification of white matter abnormalities in mild traumatic brain injury: Comparison between regional and global analysis"],"prefix":"10.1002","volume":"50","author":[{"given":"Matthew S.","family":"Davitz","sequence":"first","affiliation":[{"name":"Center for Advanced Imaging Innovation and Research (CAI<sup>2<\/sup>R), Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, Department of Radiology  New York New York 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