{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:53:41Z","timestamp":1790290421726,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1C1A2A01055423"],"award-info":[{"award-number":["2015R1C1A2A01055423"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intravoxel incoherent motion (IVIM) diffusion\u2010weighted imaging (DWI) parameters may reflect perfusion and diffusion changes in hepatic sinusoidal obstruction syndrome (SOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the feasibility of IVIM\u2010DWI in the noninvasive assessment of hepatic SOS in an experimental rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population\/Subjects<\/jats:title><jats:p>Forty\u2010four rats were administered different doses (90 or 160 mg\/kg) of monocrotaline by gavage either 48 or 72 hours before MRI to induce different degrees of hepatic SOS, and another 10 rats served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T scanner, IVIM\u2010DWI using nine b values (0\u2013800 sec\/mm<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Histologically, rats were classified as having none (<jats:italic>n<\/jats:italic> = 10), mild (<jats:italic>n<\/jats:italic> = 8), moderate (<jats:italic>n<\/jats:italic> = 19), or severe SOS (<jats:italic>n<\/jats:italic> = 17). The apparent diffusion coefficient (ADC) and IVIM\u2010derived parameters (<jats:italic>D<\/jats:italic>: true diffusion coefficient, <jats:italic>D*<\/jats:italic>: pseudo\u2010diffusion coefficient, and <jats:italic>f<\/jats:italic>: perfusion fraction) of the liver parenchyma were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>IVIM\u2010DWI parameters were compared according to histologic grades of SOS (none, mild, moderate, and severe), and receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ADC, <jats:italic>D<\/jats:italic>, and <jats:italic>f<\/jats:italic> of the liver parenchyma were significantly different according to SOS severity groups (<jats:italic>P<\/jats:italic>s &lt; 0.01) and significantly decreased as SOS severity increased (rho = \u20130.323, \u20130.313, and \u20130.700; <jats:italic>P<\/jats:italic> = 0.017, 0.021, and &lt;0.001, respectively). Means of <jats:italic>f<\/jats:italic> in none, mild, moderate, and severe SOS were 17.2%, 13.3%, 12.3%, and 11.1%, respectively. Among ADC and IVIM\u2010derived parameters, <jats:italic>f<\/jats:italic> provided the highest area under the ROC curves for detecting \u2265mild, \u2265moderate, and severe SOS (0.991, 0.890, and 0.803, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>IVIM\u2010DWI may be useful in the diagnosis and severity assessment of hepatic SOS.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage:<\/jats:bold> 2 J. Magn. Reson. Imaging 2020;51:81\u201389.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26790","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T06:34:09Z","timestamp":1557988449000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of hepatic sinusoidal obstruction syndrome with intravoxel incoherent motion diffusion\u2010weighted imaging: An experimental study in a rat model"],"prefix":"10.1002","volume":"51","author":[{"given":"Eun Kyoung","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Radiology Seoul National University Hospital  Seoul Korea"},{"name":"Department of Radiology Seoul National University College of Medicine  Seoul 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