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Sound therapy is regarded as a reasonable management option for tinnitus treatment and has been applied in the clinical setting for decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that sound therapy, a commonly used tinnitus treatment method, would alter the functional connectivity (FC) of brain regions in tinnitus models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Longitudinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Resting\u2010state functional MRI data were collected from 27 tinnitus patients before and after 12 weeks of sound therapy. Twenty\u2010seven age\u2010 and sex\u2010matched healthy controls were also longitudinally scanned at the 12\u2010week timepoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength<\/jats:title><jats:p>3.0T MRI system and echo planar imaging (EPI) sequence, 3D brain volume imaging (BRAVO) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Functional connectivity strength (FCS), a graph\u2010theoretical\u2010based analytic method, was applied to analyze the FC features in the whole brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student's <jats:italic>t<\/jats:italic>\u2010test and chi\u2010square test were used for analyses between two groups. A two\u2010way analysis of covariance (ANCOVA) followed by post\u2010hoc analyses was performed to determine differences of FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The interaction effect between the two groups and two scans on FCS was observed in the bilateral thalami and left anterior cingulate cortex (ACC). The fitted FCS values in the bilateral thalami were significantly higher in tinnitus patients at baseline and decreased to a relatively normal range after sound therapy compared with healthy controls. Conversely, the fitted FCS values in the left ACC were within the normal range, but increased after treatment (1.08\u2009\u00b1\u20090.29, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02); however, there was no change in the control group. Importantly, significant correlations were observed between the FCS changes in the right thalamus (<jats:italic>P<\/jats:italic> = 0.028), the FC of the right thalamus\u2010right inferior frontal gyrus (<jats:italic>P<\/jats:italic> = 0.015), and symptomatic improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Sound therapy may modulate the brain network by altering the gating function of the thalamus as well as enhancing the tinnitus\u2010canceling system.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage:<\/jats:bold> 4 J. Magn. Reson. Imaging 2019;50:1731\u20131741.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26796","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T18:22:45Z","timestamp":1558030965000},"page":"1731-1741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of sound therapy on resting\u2010state functional brain networks in patients with tinnitus: A graph\u2010theoretical\u2010based study"],"prefix":"10.1002","volume":"50","author":[{"given":"Lv","family":"Han","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yawen","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Beihang University  Beijing 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