{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:31:43Z","timestamp":1790105503792,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["K25 HL119608"],"award-info":[{"award-number":["K25 HL119608"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL115828"],"award-info":[{"award-number":["R01 HL115828"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","award":["16POST27250158"],"award-info":[{"award-number":["16POST27250158"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of different expressions of aortic valve disease on 3D aortic hemodynamics is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate changes in aortic hemodynamics in patients with dilated ascending aorta (AAo) but different severity of aortic valve stenosis (AS) and\/or regurgitation (AR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 111 subjects (86 patients with AAo diameter\u2009\u2265\u200940 mm and 25 healthy controls, all with trileaflet aortic valve [TAV]). Patients were further stratified by TAV dysfunction: <jats:italic>n<\/jats:italic> = 9 with combined moderate or severe AS and AR (ASR, 56\u2009\u00b1\u200913 years), <jats:italic>n<\/jats:italic> = 14 with moderate or severe AS (AS, 64\u2009\u00b1\u200914 years), <jats:italic>n<\/jats:italic> = 33 with moderate or severe AR (AR, 62\u2009\u00b1\u200914 years), <jats:italic>n<\/jats:italic> = 30 with neither AS nor AR (no AS\/AR, 63\u2009\u00b1\u20099 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>4D flow MRI on 1.5\/3T systems for the in vivo analysis of aortic blood flow dynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Data analysis included grading of 3D AAo vortex\/helix flow and AAo flow eccentricity as well as quantification of systolic peak velocities and wall shear stress (WSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Continuous variables were compared by one\u2010way analysis of variance or Kruskal\u2013Wallis, followed by a pairwise Tukey or Dunn test if there was a significant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients demonstrated markedly elevated vortex and helix flow compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Peak velocities were significantly elevated in ASR, AS, and AR patients compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Increased flow eccentricity was observed in entire AAo for AR, at the mid and distal AAo for ASR and AS, and at the proximal AAo for no AS\/AR. Compared with controls, WSS in the AAo was significantly elevated in ASR and AS patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and reduced in no AS\/AR patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The presence of TAV dysfunction is associated with aberrant hemodynamics and altered WSS, which may play a role in the development of aortopathy.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 3<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage:<\/jats:bold> 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2020;51:481\u2013491.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26804","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T12:36:14Z","timestamp":1559824574000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Aortic Valve Disease on 3D Hemodynamics in Patients With Aortic Dilation and Trileaflet Aortic Valve Morphology"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-7932","authenticated-orcid":false,"given":"Kenichiro","family":"Suwa","sequence":"first","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-5604","authenticated-orcid":false,"given":"Ozair Abdul","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Bollache","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Ann &amp; Robert H. 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