{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:08:47Z","timestamp":1791911327533,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Arterial spin labeling (ASL) is an emerging MRI technique for noninvasive measurement of cerebral blood flow (CBF) that has been used to show hemodynamic changes in the brains of people with Alzheimer's disease (AD). CBF changes have been measured using positron emission tomography (PET) across the AD spectrum, but ASL showed limited success in measuring CBF variations in the preclinical phase of AD, where amyloid \u03b2 (A\u03b2) plaques accumulate in the decades prior to symptom onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the relationship between CBF measured by multiphase\u2010pseudocontinuous\u2010ASL (MP\u2010PCASL) and A\u03b2 burden as measured by <jats:sup>11<\/jats:sup>C\u2010PiB PET imaging in a study of cognitively normal (CN) subjects age over 65.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Cross\u2010sectional.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Forty\u2010six CN subjects including 33 with low levels of A\u03b2 burden and 13 with high levels of A\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T\/3D MP\u2010PCASL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The MP\u2010PCASL method was chosen because it has a high signal\u2010to\u2010noise ratio. Furthermore, the data were analyzed using an efficient processing pipeline consisting of motion correction, ASL motion correction imprecision removal, temporal and spatial filtering, and partial volume effect correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>General Linear Model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In CN subjects positive for A\u03b2 burden (<jats:italic>n<\/jats:italic> = 13), we observed a positive correlation between CBF and A\u03b2 burden in the hippocampus, amygdala, caudate (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), frontal, temporal, and insula (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>To the best of our knowledge, this is the first study using MP\u2010PCASL in the study of AD, and the results suggest a potential compensatory hemodynamic mechanism that protects against pathology in the early stages of AD.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2020;51:505\u2013513.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26810","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T14:19:32Z","timestamp":1559225972000},"page":"505-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Increased cerebral blood flow with increased amyloid burden in the preclinical phase of alzheimer's disease"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5886-0511","authenticated-orcid":false,"given":"Amir","family":"Fazlollahi","sequence":"first","affiliation":[{"name":"CSIRO Health and Biosecurity  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Calamante","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney Imaging and School of Aerospace Mechanical and Mechatronic Engineering  Sydney Australia"},{"name":"Florey Institute of Neuroscience and Mental Health  Heidelberg Australia"},{"name":"Florey Department of Neuroscience &amp; Mental Health University of Melbourne  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Liang","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health  Heidelberg Australia"},{"name":"Mary MacKillop Institute for Health Research, Australian Catholic University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bourgeat","sequence":"additional","affiliation":[{"name":"CSIRO Health and Biosecurity  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnesh","family":"Raniga","sequence":"additional","affiliation":[{"name":"CSIRO Health and Biosecurity  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dore","sequence":"additional","affiliation":[{"name":"CSIRO Health and Biosecurity  Brisbane Australia"},{"name":"Austin Health  Heidelberg Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Fripp","sequence":"additional","affiliation":[{"name":"CSIRO Health and Biosecurity  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ames","sequence":"additional","affiliation":[{"name":"University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Florey Department of Neuroscience &amp; Mental Health University of Melbourne  Australia"},{"name":"University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Austin Health  Heidelberg Australia"},{"name":"University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Connelly","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health  Heidelberg Australia"},{"name":"Florey Department of Neuroscience &amp; Mental Health University of Melbourne  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Austin Health  Heidelberg Australia"},{"name":"University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Salvado","sequence":"additional","affiliation":[{"name":"CSIRO Health and Biosecurity  Brisbane Australia"},{"name":"CSIRO Data61  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_6_3_1","first-page":"742","article-title":"Clinical trials update: A\u03b2\u2010clearing drug fails to slow Alzheimer disease","volume":"315","author":"Slomski A.","year":"2016","journal-title":"JAMA"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22173"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.028"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.12.173"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.182"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.051946"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15605847"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3114"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1402-13.2013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055847.17752.E6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10669"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf185"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.7.950"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.204"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23579"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.10"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1462"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.92"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu043"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2343031499"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.07.016"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.05.048"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209009405"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ima.22006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-47118-1_14"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.044"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-00928-1_8"},{"key":"e_1_2_6_34_1","unstructured":"DoluiS WolfR Ali NabavizadehS WolkD DetreJ. Automated quality evaluation index for 2D ASL CBF maps. In:International Society for Magnetic Resonance in Medicine \u2014 ISMRM2017:682."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.05.001"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2503080751"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132252"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120292"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.003"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr255"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.1062"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.26810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.26810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:36:09Z","timestamp":1693193769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.26810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,30]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jmri.26810"],"URL":"https:\/\/doi.org\/10.1002\/jmri.26810","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,30]]},"assertion":[{"value":"2019-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}