{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:12:58Z","timestamp":1770725578895,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We sought to replace full\u2010dose Gd\u2010DTPA with safer and lower\u2010dose contrast agents for delayed gadolinium\u2010enhanced MRI of cartilage (dGEMRIC). Gd\u2010BOPTA has a lower intrinsic nephrogenic systemic fibrosis risk and a 2\u2010fold higher relaxivity at 3T; thus, the contrast agent dose may be halved, further reducing contrast agent\u2010dependent risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the feasibility of using half\u2010dose, high\u2010relaxivity Gd\u2010BOPTA vs. standard\u2010dose Gd\u2010DTPA for dGEMRIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Eleven healthy volunteers (five women, mean age 25.7 years) and 10 patients with knee pain (three women, mean age 36.7 years; nine with chondromalacia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequences<\/jats:title><jats:p>3D T<jats:sub>1<\/jats:sub>\u2010weighted volumetric breath\u2010hold examination (VIBE) sequence at 3T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Knee dGEMRIC was performed twice, first using 0.1 mmol\/kg Gd\u2010BOPTA and 4 weeks later using 0.2 mmol\/kg Gd\u2010DTPA. Contrast penetration was studied using pre\u2010 and 60\u2013120\u2010min postcontrast imaging in volunteers and pre\u2010 and 90\u2010min postcontrast imaging in patients. Femoral cartilage lesions were assessed using modified whole\u2010organ MRI scores. Healthy cartilage and partial\u2010thickness lesions were compared using region\u2010of\u2010interest analyses by independent readers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Linear mixed\u2010effect\u2010models, area under receiver\u2010operating\u2010characteristic curve (AUC) analysis, intraclass correlation (ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In healthy volunteers, Gd\u2010BOPTA and Gd\u2010DTPA T<jats:sub>1<\/jats:sub>\u2010values did not differ significantly at any timepoint (<jats:italic>P<\/jats:italic> = 0.164\u20130.995). In patients, Gd\u2010BOPTA T<jats:sub>1<\/jats:sub>\u2010values (743.33\u2009\u00b1\u200972.015 msec) were higher than Gd\u2010DTPA T<jats:sub>1<\/jats:sub>\u2010values (681.24\u2009\u00b1\u200967.635 msec, <jats:italic>P<\/jats:italic> = 0.030). Gd\u2010BOPTA and Gd\u2010DTPA detected chondromalacia areas equally well, with significantly lower T<jats:sub>1<\/jats:sub>\u2010values than in healthy cartilage (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and nonsignificantly different AUCs (0.92 and 0.96, <jats:italic>P<\/jats:italic> = 0.27). The absolute decrease in T<jats:sub>1<\/jats:sub>\u2010values between healthy and pathological cartilage was similar (Gd\u2010BOPTA: 149.59 msec; Gd\u2010DTPA: 149.44 msec, <jats:italic>P<\/jats:italic> = 0.99). ICCs were 0.83\u20130.98 for Gd\u2010BOPTA and 0.80\u20130.98 for Gd\u2010DTPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Gd\u2010BOPTA might be used at half the Gd\u2010DTPA dose in dGEMRIC, with similar contrast penetration and T<jats:sub>1<\/jats:sub>\u2010values in healthy cartilage and noninferior detection of cartilage damage.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 5 J. Magn. Reson. Imaging 2020;51:144\u2013154.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26816","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T12:52:38Z","timestamp":1559134358000},"page":"144-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feasibility of using half\u2010dose Gd\u2010BOPTA for delayed gadolinium\u2010enhanced MRI of cartilage (dGEMRIC) at the knee, compared with standard\u2010dose Gd\u2010DTPA"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-8711","authenticated-orcid":false,"given":"Christoph","family":"Rehnitz","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastian","family":"Klaan","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology University Medicine Rostock  Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Burkholder","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health University of Applied Sciences of the Saarland  Saarbruecken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Bari\u00e9","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Wuennemann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Ulrich","family":"Kauczor","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2010Andr\u00e9","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology University Medicine Rostock  Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.04.020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21388"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200310000-00019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.04.029"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22555"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199905)41:5<857::AID-MRM1>3.0.CO;2-E"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20482"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2008.11.019"},{"key":"e_1_2_6_10_1","unstructured":"ACR Committee on Drugs and Contrast Media. 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