{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:14:14Z","timestamp":1787314454971,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In amyotrophic lateral sclerosis (ALS), motor neurons in the brainstem markedly deplete, whereas sensory neurons are less severely affected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether facial nerve (FN) measurement on 3D fast imaging employing steady\u2010state acquisition (FIESTA) is useful for ALS diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>Fifteen ALS patients and 16 controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3T FIESTA MR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>The cross\u2010sectional area of the FN and cochlear nerve (CN) were measured, and the FN\/CN ratio (FCR) was assessed. For qualitative assessment, the FN cross\u2010sectional area was compared with that of the CN and the following scores were assigned: score 1 (large), the FN is larger than the CN; score 2 (almost equal), the size difference between the FN and CN is within 10%; score 3 (small), the FN is smaller than the CN (10\u201350%); score 4 (significantly small), size of the FN is less than half the size of the CN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      The differences in FCR between the ALS patients and the controls were tested using the Wilcoxon Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test. For the qualitative and quantitative assessments, we performed a receiver operating characteristic analysis for the diagnosis of ALS with an abnormal finding as score 3 or 4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean FCR was significantly smaller for ALS patients (0.71\u2009\u00b1\u20090.17) than for controls (0.95\u2009\u00b1\u20090.08) (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and the area under the curve was 0.93. When an FN score was 3 or 4, indicative of FN atrophy, the sensitivity and specificity values of FIESTA for discriminating ALS patients from controls were 93.3% (14\/15) and 90.0% (18\/20), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>The FN atrophy revealed on FIESTA, which may reflect lower motor neuron impairment in ALS, allowed us to distinguish ALS patients from controls with a high degree of accuracy.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Level of Evidence:<\/jats:bold>\n                      3\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Technical Efficacy:<\/jats:bold>\n                      Stage 2\n                    <\/jats:p>\n                    <jats:p>J. Magn. Reson. Imaging 2020;51:757\u2013766.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.26890","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T21:00:07Z","timestamp":1565384407000},"page":"757-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Facial nerve atrophy in patients with amyotrophic lateral sclerosis: Evaluation with fast imaging employing steady\u2010state acquisition (FIESTA)"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8837-9593","authenticated-orcid":false,"given":"Mari","family":"Miyata","sequence":"first","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kakeda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Hirosaki University Graduate School of Medicine 5 Zaifu\u2010cho  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8132-5592","authenticated-orcid":false,"given":"Tomoyo","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, School of Medicine  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Occupational and Environmental Health, School of Medicine  Kitakyushu 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