{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:04:14Z","timestamp":1764687854515},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with transposition of the great arteries (TGA) have an altered aortic geometry after an arterial switch operation (ASO), with neo\u2010aortic root dilatation as an important complication. Geometry\u2010related aortic hemodynamics have been assumed to contribute to pathology of the ascending aorta (AAo).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate aortic flow displacement (FD) and regional wall shear stress (WSS) in relation to ascending neo\u2010aortic geometry in children after ASO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010eight TGA patients after ASO and 10 healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T\/4D flow (segmented fast\u2010spoiled echo pulse), noncontrast\u2010enhanced MR angiography (Dixon), and anatomic images (SSFP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Aortic diameters and body surface area\u2010indexed aortic dimensions (Z\u2010scores), normalized FD and planar ascending aortic WSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Mann\u2013Whitney and chi\u2010square tests for differences in FD magnitude, WSS, and FD directionality between groups, respectively. Spearman rank correlation to assess the degree of association between aortic geometry, FD and WSS parameters. Shapiro\u2013Wilk test to evaluate distribution normality on the absolute differences in octant location between FD and WSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TGA patients showed a significantly dilated proximal AAo and relatively small mid\u2010AAo dimensions at the level of the pulmonary arteries (Z\u2010scores neo\u2010aortic root: 4.38\u2009\u00b1\u20091.96 vs. 1.52\u2009\u00b1\u20090.70, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; sinotubular junction: 3.48\u2009\u00b1\u20092.67 vs. 1.38\u2009\u00b1\u20091.30, <jats:italic>P<\/jats:italic> = 0.010; mid\u2010AAo: 0.32\u2009\u00b1\u20093.06 vs. 1.69\u2009\u00b1\u20091.24, <jats:italic>P<\/jats:italic> = 0.001). FD magnitude was higher in TGA patients (neo\u2010aortic root: 0.048\u2009\u00b1\u20090.027 vs. 0.021\u2009\u00b1\u20090.006, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; sinotubular junction: 0.054\u2009\u00b1\u20090.037 vs. 0.029\u2009\u00b1\u20090.013, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and was related to the neo\u2010aortic Z\u2010score. Clear areas of higher WSS at the right and anterior aortic wall regions along the distal AAo were detected in TGA patients, most pronounced in those with relatively smaller mid\u2010AAo diameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>TGA\u2010specific geometry related to the ASO, evidenced by neo\u2010aortic root dilatation and a sudden change in vessel diameter at mid\u2010AAo level, leads to more aortic flow asymmetry in the proximal AAo and WSS distribution with higher WSS at the right and anterior aortic wall regions along the distal AAo.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage:<\/jats:bold> 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2020;51:1105\u20131116.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.26934","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T03:34:47Z","timestamp":1570505687000},"page":"1105-1116","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Altered Ascending Aorta Hemodynamics in Patients After Arterial Switch Operation for Transposition of the Great Arteries"],"prefix":"10.1002","volume":"51","author":[{"given":"Roel L.F.","family":"van der Palen","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quirine S.","family":"Deurvorst","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia J.M.","family":"Kroft","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter J.","family":"van den Boogaard","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Hazekamp","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico A.","family":"Blom","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildo J.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos J.M.","family":"Westenberg","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno A.W.","family":"Roest","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"461","article-title":"Successful anatomic correction of transposition of the great vessels. A preliminary report","volume":"28","author":"Jatene AD","year":"1975","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.004618"},{"key":"e_1_2_5_4_1","article-title":"Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation","author":"Palen RLF","year":"2019","journal-title":"Heart"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2998-4"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22458"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0174-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3182034fc2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0345-7"},{"issue":"9","key":"e_1_2_5_10_1","article-title":"Aortic valve stenosis alters expression of regional aortic wall shear stress: New insights from a 4\u2010dimensional flow magnetic resonance imaging study of 571 subjects","volume":"6","author":"Ooij P","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000528"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003026"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000064"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1310"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.521617"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-84"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-018-0688-6"},{"key":"e_1_2_5_18_1","first-page":"695 e691","article-title":"Non\u2010contrast enhanced navigator\u2010gated balanced steady state free precession magnetic resonance angiography as a preferred magnetic resonance technique for assessment of the thoracic aorta","volume":"72","author":"Kesteren F","year":"2017","journal-title":"Clin Radiol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.015"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-10-56"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22800"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu026"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.04.026"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305702"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs169"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.06.058"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5539"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25719"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.01.042"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2015.00107"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874120701711010009"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01423-5"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivw014"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25773"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24847"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25081"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22519"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.26934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.26934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:48:40Z","timestamp":1694015320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.26934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,7]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/jmri.26934"],"URL":"https:\/\/doi.org\/10.1002\/jmri.26934","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,7]]},"assertion":[{"value":"2019-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}