{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:26:53Z","timestamp":1792798013723,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"\u2018Cardio Vascular Imaging Group (CVIG)\u2019"},{"name":"Leiden University Medical Centre"},{"name":"Novo Nordisk A\/S"},{"name":"Roba Metals B.V. IJsselstein"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonist liraglutide may be beneficial in the regression of diabetic cardiomyopathy. South Asian ethnic groups in particular are at risk of developing type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the effects of liraglutide on left ventricular (LV) diastolic and systolic function in South Asian type 2 diabetes patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective, double\u2010blind, randomized, placebo\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Forty\u2010seven type 2 diabetes patients of South Asian ancestry living in the Netherlands, with or without ischemic heart disease, who were randomly assigned to 26\u2010week treatment with liraglutide (1.8 mg\/day) or placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>\n                      3T (balanced steady\u2010state free precession cine MRI, 2D and 4D velocity\u2010encoded MRI,\n                      <jats:sup>1<\/jats:sup>\n                      H\u2010MRS, T\n                      <jats:sub>1<\/jats:sub>\n                      mapping).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Primary endpoints were changes in LV diastolic function (early deceleration peak [Edec], ratio of early and late peak filling rate [E\/A], estimated LV filling pressure [E\/Ea]) and LV systolic function (ejection fraction). Secondary endpoints were changes in aortic stiffness (aortic pulse wave velocity [PWV]), myocardial steatosis (myocardial triglyceride content), and diffuse fibrosis (extracellular volume [ECV]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>Data were analyzed according to intention\u2010to\u2010treat. Between\u2010group differences were reported as mean (95% confidence interval [CI]) and were assessed using analysis of covariance (ANCOVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Liraglutide (\n                      <jats:italic>n<\/jats:italic>\n                      = 22) compared with placebo (\n                      <jats:italic>n<\/jats:italic>\n                      = 25) did not change Edec (+0.2 mL\/s\n                      <jats:sup>2<\/jats:sup>\n                      \u00d7 10\n                      <jats:sup>\u20103<\/jats:sup>\n                      (\u20130.3;0.6)), E\/A (\u20130.09 (\u20130.23;0.05)), E\/Ea (+0.1 (\u20131.2;1.3)) and ejection fraction (0% (\u20133;2)), but decreased stroke volume (\u20139 mL (\u201314;\u20135)) and increased heart rate (+10 bpm (4;15)). Aortic PWV (+0.5 m\/s (\u20130.6;1.6)), myocardial triglyceride content (+0.21% (\u20130.09;0.51)), and ECV (\u20130.2% (\u20131.4;1.0)) were unaltered.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Liraglutide did not affect LV diastolic and systolic function, aortic stiffness, myocardial triglyceride content, or extracellular volume in Dutch South Asian type 2 diabetes patients with or without coronary artery disease.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Level of Evidence:<\/jats:bold>\n                      1\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Technical Efficacy Stage:<\/jats:bold>\n                      4\n                    <\/jats:p>\n                    <jats:p>J. Magn. Reson. Imaging 2020;51:1679\u20131688.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.27009","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T08:21:09Z","timestamp":1575447669000},"page":"1679-1688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effect of Liraglutide on Cardiovascular Function and Myocardial Tissue Characteristics in Type 2 Diabetes Patients of South Asian Descent Living in the Netherlands: A Double\u2010Blind, Randomized, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8948-7860","authenticated-orcid":false,"given":"Elisabeth H.M.","family":"Paiman","sequence":"first","affiliation":[{"name":"Department of Radiology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huub J.","family":"van Eyk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Leiden University Medical Centre  Leiden the Netherlands"},{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minke M.A.","family":"van Aalst","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice B.","family":"Bizino","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.","family":"van der Geest","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos J.M.","family":"Westenberg","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronella H.","family":"Geelhoed\u2010Duijvestijn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haaglanden Medical Centre The Hague  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aan V.","family":"Kharagjitsingh","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology University Hospital Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.N.","family":"Rensen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Leiden University Medical Centre  Leiden the Netherlands"},{"name":"Einthoven 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