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The regions of interest (ROIs) were selected at the infarcted myocardium (with\/without intramyocardial hemorrhage [IMH] and microvascular obstruction [MVO]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>One\u2010way analysis of variance and the Kruskal\u2013Wallis test were used for the statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Native T<jats:sub>1<\/jats:sub> of MI (without MVO\/IMH) gradually decreased after reperfusion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The ECV of MI increased during the first 3\u2009days and then slowly declined. Native T<jats:sub>1<\/jats:sub> of MI with MVO\/IMH was the lowest (1184 msec; 1108.5\u20131266), while ECV (78%; 65.5\u201387%) was the highest, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001. Native T<jats:sub>1<\/jats:sub> and ECV of salvageable myocardium were higher than those of the remote myocardium but lower than those of the MI without MVO or IMH (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). ROC analysis revealed an area under the curve (AUC) of ECV (0.85, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) for differentiating infarcted and salvageable myocardium was higher than that of native T<jats:sub>1<\/jats:sub> mapping (AUC: 0.63, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in the first week after STEMI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). T<jats:sub>1<\/jats:sub> and ECV differed significantly between patients with and without left ventricle adverse remodeling (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Dynamic temporal changes in reversibly and irreversibly damaged myocardia were differentiated via native T<jats:sub>1<\/jats:sub> and ECV mapping after primary percutaneous coronary intervention in STEMI patients. ECV may better reflect microvascular injury severity and myocardial viability. MI with higher native T<jats:sub>1<\/jats:sub> and ECV or with severe microvascular injury (MVO and IMH) was correlated with adverse LV remodeling.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage:<\/jats:bold> 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2020. J. Magn. Reson. Imaging 2020;52:476\u2013487.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27047","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T09:57:24Z","timestamp":1578995844000},"page":"476-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Myocardial Extracellular Volume Fraction Allows Differentiation of Reversible Versus Irreversible Myocardial Damage and Prediction of Adverse Left Ventricular Remodeling of ST\u2010Elevation Myocardial Infarction"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-8416","authenticated-orcid":false,"given":"Bing\u2010Hua","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai 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