{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T12:29:39Z","timestamp":1773491379106,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The poor prognosis of cardiac sarcoidosis (CS) underscores the need for risk stratification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the prognostic significance of ventricular\/myocardial remodeling features in sarcoidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 132 biopsy\u2010proven sarcoidosis patients imaged from 2008 to 2018. The primary endpoint was a composite of cardiac mortality, new onset arrhythmias, hospitalization for heart failure, and device implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>No field strength or sequence restrictions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Global and regional ventricular\/myocardial remodeling features were assessed by standard volumetric measurements and automated function imaging postprocessing analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student's <jats:italic>t<\/jats:italic>\u2010test or Mann\u2013Whitney test (chi<jats:sup>2<\/jats:sup> test or Fisher's exact test for categorical variables) were used for comparisons. Cox\u2010proportional hazards regression model, univariate \/multivariate analyses, and receiver operating characteristic were performed to relate clinical\/lab data, imaging parameters to the endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median follow\u2010up of 40.7 (interquartile range 18.8\u201360.5) months, 41 (31.1%) patients developed adverse cardiac events. Abnormal left ventricular (LV) geometric remodeling alterations (measured by LV mass index and relative wall thickness) occurred 3.66\u2010fold more frequently in patients with endpoints than patients without. The ratio of patients with endpoints increased as ventricular remodeling phenotype progressed. In patients with endpoints, regional myocardial wall thickness (RMWT) was significantly (<jats:italic>P<\/jats:italic> = 0.022) increased in six clustered LV segments located in the middle interventricular septum and basal\/middle anterolateral walls. In all of the abnormal ventricular remodeling stages, patients with endpoints constantly had higher mean RMWT than those without. Among clinical, electrocardiographic, and imaging parameters, LV mass index (hazard ratio [HR] 1.010 95% confidence interval [CI] 1.002\u20131.018, <jats:italic>P<\/jats:italic> = 0.017) and mean RMWT (HR 3.482 95% CI 1.679\u20137.223, <jats:italic>P<\/jats:italic> = 0.001) were independently associated with endpoints. Sarcoidosis patients without this RMWT distribution pattern were significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) more likely to be free of the occurrence of subsequent cardiac events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Regional myocardial remodeling characteristics are associated with subsequent adverse cardiac events in sarcoidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2 J. Magn. Reson. Imaging 2020;52:499\u2013509.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27057","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T07:41:19Z","timestamp":1579246879000},"page":"499-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regional Myocardial Remodeling Characteristics Correlates With Cardiac Events in Sarcoidosis"],"prefix":"10.1002","volume":"52","author":[{"given":"Chenying","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Medicine and Radiology State University of New York, Upstate Medical University Hospital  Syracuse New York USA"},{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive and Intervention Research Lishui Hospital, Zhejiang University School of Medicine  Lishui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of 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