{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:12:54Z","timestamp":1758633174811,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR067789"],"award-info":[{"award-number":["R01 AR067789"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K07 CA166177"],"award-info":[{"award-number":["K07 CA166177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Current methods to predict height and growth failure are imprecise. MRI measures of physeal cartilage are promising biomarkers for growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In the physis, to assess how 3D MRI volume measurements, and diffusion tensor imaging (DTI) measurements (tract volume and length) correlate with growth parameters and detect differences in growth. We compared patients exposed to cis\u2010retinoic acid, which causes physeal damage and growth failure, with normal subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Case\u2013control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty pediatric neuroblastoma survivors treated with cis\u2010retinoic acid and 20 age\u2010 and sex\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T; DTI and 3D double\u2010echo steady\u2010state (DESS) sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>On distal femoral MR studies, physeal 3D volume and DTI tract measurements were calculated and compared to height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>We used partial Spearman correlation, analysis of covariance, logistic regression, Wald test, and the intraclass correlation coefficient (ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The height percentile correlated most strongly with DTI tract volumes (<jats:italic>r =<\/jats:italic> 0.74), followed by mean tract length (<jats:italic>r =<\/jats:italic> 0.53) and 3D volume (<jats:italic>r =<\/jats:italic> 0.40) (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02). Only tract volumes and lengths correlated with annualized growth velocity. Relative to controls, patients showed smaller tract volumes (8.00\u2009cc vs. 13.71\u2009cc, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), shorter tract lengths (5.92\u2009mm vs 6.99\u2009mm, <jats:italic>P<\/jats:italic> = 0.03), and smaller ratios of 3D cartilage volume to tract length; but no difference (4.51\u2009cc vs 4.85\u2009cc) in 3D MRI volumes. The 10 patients with the lowest height percentiles had smaller tract volumes (5.07\u2009cc vs. 10.93\u2009cc, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), but not significantly different 3D MRI volumes. Tract volume is associated with abnormal growth, with an accuracy of 75%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>DTI tract volume of the physis\/metaphysis predicts abnormal growth better than physeal cartilage volumetric measurement and correlates best with height percentile and growth velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2 J. Magn. Reson. Imaging 2020;52:544\u2013551.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27076","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T10:41:23Z","timestamp":1581331283000},"page":"544-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Imaging Biomarkers of the Physis: Cartilage Volume on MRI vs. Tract Volume and Length on Diffusion Tensor Imaging"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-9603","authenticated-orcid":false,"given":"Phuong","family":"Duong","sequence":"first","affiliation":[{"name":"Department of Radiology Columbia University Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sogol","family":"Mostoufi\u2010Moab","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 G.","family":"Raya","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU Langone Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Jaimes","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Department of Radiology Columbia University Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329372"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(52)80205-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132136"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017160681"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-019-04443-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-019-04409-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2018.61.7.226"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06247-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26124"},{"key":"e_1_2_7_11_1","unstructured":"WangR BennerT SorensenA WedeenV. Diffusion toolkit: A software package for diffusion imaging data processing and tractography [abstr]. In: Proc 15th Annual Meeting ISMRM Berkeley CA; 2007."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163040-00013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198668020-00010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.05.021"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050206"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(05)70313-4"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.27076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.27076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:27:23Z","timestamp":1693891643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.27076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/jmri.27076"],"URL":"https:\/\/doi.org\/10.1002\/jmri.27076","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"type":"print","value":"1053-1807"},{"type":"electronic","value":"1522-2586"}],"subject":[],"published":{"date-parts":[[2020,2,10]]},"assertion":[{"value":"2019-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}