{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:43:37Z","timestamp":1788633817044,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61971425"],"award-info":[{"award-number":["61971425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603631"],"award-info":[{"award-number":["81603631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771918"],"award-info":[{"award-number":["81771918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>As one of the most prevalent sexual dysfunctions in men, lifelong premature ejaculation (PE) often leads to patient distress. The hypothalamus is implicated in the ejaculatory control of healthy males. However, we do not know whether the hypothalamus\u2010related intrinsic connectivity is altered in lifelong PE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate abnormal intrinsic connectivity of the hypothalamus in lifelong PE patients compared with healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective pilot study using cross\u2010sectional data of patients and HCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Forty\u2010seven lifelong PE patients and 30 HCs were included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T MRI scanner for T<jats:sub>1<\/jats:sub>\u2010weighted imaging using spoiled gradient recalled echo sequence and functional imaging using a single\u2010shot gradient recalled echo sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Preprocessing of MRI data and hypothalamus\u2010seeded functional connectivity (FC) computation were performed using DPABI4.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The two\u2010sample <jats:italic>t<\/jats:italic>\u2010test within SPM12 was adopted to examine possible alterations of intrinsic connectivity of hypothalamus in lifelong PE patients compared with HCs including anxiety and depression scores as covariates (false discovery rate\u2010corrected, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The correlation analysis was then used to assess possible associations between the imaging findings and clinical features in the patient group (Bonferroni\u2010corrected, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, lifelong PE patients had decreased hypothalamus\u2010seeded FC in the left orbitofrontal cortex, bilateral insula, superior temporal cortex, superior temporal pole, middle temporal cortex, left fusiform, right parahippocampal gyrus, and right cerebellum. The intravaginal ejaculatory latency time positively correlated with the mean z\u2010score from the hypothalamus\u2010insula (<jats:italic>r =<\/jats:italic> 0.45) and hypothalamus\u2010cerebellum (<jats:italic>r =<\/jats:italic> 0.48) intrinsic connectivity, separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>We have shown that hypothalamus\u2010seeded FC alterations and the correlations between the aforementioned abnormal FC alterations and intravaginal ejaculatory latency time. The current findings may promote the understanding of the hypothalamus\u2010related neural mechanisms involved in the abnormal ejaculatory information processing in lifelong PE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>3 J. Magn. Reson. Imaging 2020;52:778\u2013784.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27099","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T14:52:13Z","timestamp":1582037533000},"page":"778-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Altered Functional Connectivity of Hypothalamus in Lifelong Premature Ejaculation Patients"],"prefix":"10.1002","volume":"52","author":[{"given":"Ming","family":"Gao","sequence":"first","affiliation":[{"name":"Assisted Reproduction Center Northwest Women and Children Hospital Affiliated to Xi'an JiaoTong University  Xi'an China"},{"name":"Department of Andrology XiYuan Hospital, China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Feng","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology, Xidian 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