{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:44:23Z","timestamp":1784691863822,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key projects of the Chinese Ministry of Science and Technology","award":["2019YFC0119900"],"award-info":[{"award-number":["2019YFC0119900"]}]},{"name":"Multi-center clinical research plan of medical college of Shanghai Jiao Tong University","award":["DLY201823"],"award-info":[{"award-number":["DLY201823"]}]},{"name":"Shanghai Leadership Talent Training Plan","award":["2017062"],"award-info":[{"award-number":["2017062"]}]},{"name":"Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support","award":["20152233"],"award-info":[{"award-number":["20152233"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The sensitivity of endolymphatic hydrops (EH) to the glycerol test varies in patients with Meni\u00e8re's disease (MD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the features of EH and its glycerol\u2010induced dynamics in MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty patients with MD (24 affected ears) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T 3D\u2010FLAIR (fluid\u2010attenuated inversion recovery) MRI and late gadolinium enhancement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Intratympanic gadolinium\u2010enhanced MRI was performed in the MD\u2010affected ears before and after the glycerol test. The borders of the endolymphatic and total lymphatic space were contoured on the axial MRI slices to evaluate the volume of hydrops in both the cochlear and vestibular regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Paired and unpaired <jats:italic>t<\/jats:italic>\u2010tests, the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test, linear discriminant analysis, Pearson's correlation, and linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After glycerol ingestion, vestibular EH decreased in all patients, whereas cochlear EH significantly decreased only in patients with positive glycerol test results (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). At baseline, cochlear EH in the positive result group was greater than in the negative result group (<jats:italic>P<\/jats:italic> = 0.007). Unexpectedly, in the positive result group a drastic glycerol\u2010induced dehydrating effect was observed in patients whose pretest cochlear EH ratio was &gt;16% (<jats:italic>P<\/jats:italic> = 0.011). Moreover, the dehydrating role of glycerol was positively correlated with the baseline cochlear hydrops level (<jats:italic>r<\/jats:italic> = 0.7691, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>MRI provides evidence that glycerol administration improves the hearing threshold via dehydrating the EH. In the cochlear region, the baseline level of cochlear EH is a closely related factor for the validity of the glycerol test, whereas EH is consistently dehydrated in the vestibular component.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>3 J. Magn. Reson. Imaging 2020;52:1066\u20131073.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27127","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T14:08:22Z","timestamp":1583935702000},"page":"1066-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Contrast\u2010Enhanced MRI Combined With the Glycerol Test Reveals the Heterogeneous Dynamics of Endolymphatic Hydrops in Patients With Meni\u00e8re's Disease"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-2746","authenticated-orcid":false,"given":"Pengjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head &amp; Neck Surgery The Sixth People's Hospital Affiliated to Shanghai Jiaotong University  Shanghai 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Sixth People's Hospital Affiliated to Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1998-3281","authenticated-orcid":false,"given":"Haibo","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head &amp; Neck Surgery The Sixth People's Hospital Affiliated to Shanghai Jiaotong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Sleep Disordered Breathing  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Center for Otolaryngology\u2013Head &amp; Neck Surgery of Chinese PLA, Changhai Hospital, Second Military Medical University  Shanghai China"},{"name":"Hearing and Balance Research Unit, Field of Otolaryngology School of Medicine, Faculty of Medicine and Health Technology, 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