{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:33:29Z","timestamp":1787502809681,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NHLBI T32 HL134633"],"award-info":[{"award-number":["NHLBI T32 HL134633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 HL132357"],"award-info":[{"award-number":["R21 HL132357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood flow reversal is a possible mechanism for retrograde embolism in the setting of high\u2010risk atherosclerotic plaques in the descending aorta (DAo). Evidence suggests that pulse wave velocity (PWV) is a determinant of blood flow reversal and can be reduced by the destiffening effect of renin\u2010angiotensin system inhibitors (RASI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the impact of antihypertensive therapy on in vivo changes in PWV and flow reversal in patients with cryptogenic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Sixteen patients (69\u2009\u00b1\u20099\u2009years; 10 males) included after cryptogenic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>\n                      3T.\n                      <jats:styled-content style=\"fixed-case\">4D<\/jats:styled-content>\n                      flow sequence (temporal resolution = 19.6\u2009msec)\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Patients underwent aortic MRI at baseline and at 6\u2010month follow\u2010up. Patients received standard\u2010of\u2010care antihypertensive therapy that were classified as RASI vs. non\u2010RASI medications (ie, destiffening vs. nondestiffening).We compared aortic PWV, flow reversal fraction (FRF), aortic measurements, cardiac function, and other aortic and cardiac measurements in the antihypertensive therapy groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Two\u2010tailed paired or unpaired Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests (normal distributions) or Wilcoxon tests (nonnormal distribution). Univariate correlations using Pearson correlation coefficients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant decrease in PWV in the RASI (\n                      <jats:italic>n =<\/jats:italic>\n                      10) group (9.4\u2009\u00b1\u20091.6\u2009m\/s vs. 8.3\u2009\u00b1\u20091.9\u2009m\/s;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), as well as FRF (18.6%\u2009\u00b1\u20094.1% vs. 16.3%\u2009\u00b1\u20094.0%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) between baseline and the 6\u2010month MRI studies. There were no changes in PWV or FRF in the non\u2010RASI (\n                      <jats:italic>n =<\/jats:italic>\n                      6) group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.146 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.32). A decrease in FRF was significantly correlated with a decrease in PWV (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.53;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>The findings of our study suggest that RASI therapy after cryptogenic stroke resulted in a decrease of blood flow reversal and aortic stiffness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>1<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy Stage<\/jats:title>\n                    <jats:p>4<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.27279","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T03:01:06Z","timestamp":1596855666000},"page":"213-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Renin Angiotensin System Inhibitors Reduce Aortic Stiffness and Flow Reversal After a Cryptogenic Stroke"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4165-6113","authenticated-orcid":false,"given":"Gilles","family":"Soulat","sequence":"first","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0419-5541","authenticated-orcid":false,"given":"Kelly","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-0780","authenticated-orcid":false,"given":"Ashitha","family":"Pathrose","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Vali","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Biomedical Engineering, McCormick School of Engineering Northwestern University  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer A.","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menhel","family":"Kinno","sequence":"additional","affiliation":[{"name":"Loyola's Center for Heart &amp; Vascular Medicine, Stritch School of Medicine Loyola University Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Prabhakaran","sequence":"additional","affiliation":[{"name":"Neurology The University of Chicago Biological Sciences  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Biomedical Engineering, McCormick School of Engineering Northwestern University  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1503946"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312202"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025813"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006226"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006211"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005190"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.616573"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.629725"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.530030"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.577775"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06104-z"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00647.2013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01318"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05236"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05357"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307948"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.09.024"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.633487"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000065428.03209.64"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03282"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.106.085738"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22353"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22856"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0461-z"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25862"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002224"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23877"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2014.08.021"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-35"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.04.010"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.005617"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0174-5"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27747"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26986"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001299"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27684"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28257"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.27279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.27279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T02:48:48Z","timestamp":1693795728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.27279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jmri.27279"],"URL":"https:\/\/doi.org\/10.1002\/jmri.27279","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,7]]},"assertion":[{"value":"2020-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}