{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:27:22Z","timestamp":1760016442095,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["BHF FS\/15\/54\/31639","RE\/13\/5\/3017"],"award-info":[{"award-number":["BHF FS\/15\/54\/31639","RE\/13\/5\/3017"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","award":["ETM\/263"],"award-info":[{"award-number":["ETM\/263"]}],"id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Segmental extent of infarction assessed by late gadolinium enhancement (LGE) imaging early post\u2010ST\u2010segment elevation myocardial infarction (STEMI) has utility in predicting left ventricular functional recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that segmental circumferential strain with displacement encoding with stimulated echoes (DENSE) would be a stronger predictor of infarct transmurality than feature\u2010tracking strain, and noninferior to extracellular volume fraction (ECV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fifty participants (mean\u2009\u00b1\u2009SD, 59\u2009\u00b1\u20099\u2009years, 40 [80%] male) underwent cardiac MRI on day 1 post\u2010STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field\u2010Strength\/Sequences<\/jats:title><jats:p>1.5T\/cine, <jats:styled-content style=\"fixed-case\">DENSE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">T<jats:sub>1<\/jats:sub><\/jats:styled-content> mapping, <jats:styled-content style=\"fixed-case\">ECV<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LGE.<\/jats:styled-content><\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Two observers assessed segmental percentage LGE extent, presence of microvascular obstruction (MVO), circumferential and radial strain with DENSE and feature\u2010tracking, T<jats:sub>1<\/jats:sub> relaxation times, and ECV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Normality was tested using the Shapiro\u2013Wilk test. Skewed distributions were analyzed utilizing Mann\u2013Whitney or Kruskal\u2013Wallis tests and normal distributed data using independent <jats:italic>t<\/jats:italic>\u2010tests. Diagnostic cutoff values were identified using the Youden index. The difference in area under the curve was compared using the z\u2010statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Segmental circumferential strain with DENSE was associated with the extent of infarction \u226550% (AUC [95% CI], cutoff value = 0.9 [0.8, 0.9], \u221210%) similar to ECV (AUC = 0.8 [0.8, 0.9], 37%) (<jats:italic>P<\/jats:italic> = 0.117) and superior to feature\u2010tracking circumferential strain (AUC = 0.7[0.7, 0.8], \u221219%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). For the detection of segmental infarction \u226575%, circumferential strain with DENSE (AUC = 0.9 [0.8, 0.9], \u221210%) was noninferior to ECV (AUC = 0.8 [0.7, 0.9], 42%) (<jats:italic>P<\/jats:italic> = 0.132) and superior to feature\u2010tracking (AUC = 0.7 [0.7, 0.8], \u221213%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). For MVO detection, circumferential strain with DENSE (AUC = 0.8 [0.8, 0.9], \u221212%) was superior to ECV (AUC = 0.8 [0.7, 0.8] 34%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and feature\u2010tracking (AUC = 0.7 [0.6, 0.7] \u221221%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Circumferential strain with DENSE is a functional measure of infarct severity and may remove the need for gadolinium contrast agents in some circumstances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>5 J. MAGN. RESON. IMAGING 2020;52:1722\u20131731.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27295","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T06:58:17Z","timestamp":1595919497000},"page":"1722-1731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Displacement Encoding With Stimulated Echoes Enables the Identification of Infarct Transmurality Early Postmyocardial Infarction"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-7440","authenticated-orcid":false,"given":"Kenneth","family":"Mangion","sequence":"first","affiliation":[{"name":"British Heart Foundation Glasgow Cardiovascular Research Centre University of Glasgow  Glasgow UK"},{"name":"West of Scotland Heart and Lung Centre Golden Jubilee National Hospital  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher 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