{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:36Z","timestamp":1791910776710,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873886"],"award-info":[{"award-number":["81873886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873887"],"award-info":[{"award-number":["81873887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute myocardial infarction (AMI) is a disease with high morbidity and mortality worldwide and the evaluation of myocardial injury and perfusion status following myocardial ischemia and reperfusion is of clinical value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the diagnostic utility of simplified perfusion fraction (SPF) in differentiating salvage and infarcted myocardium and its predictive value for left ventricular remodeling in patients with reperfusion ST\u2010segment elevation myocardial infarction (STEMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Forty\u2010one reperfused STEMI patients and 20 healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T MRI. The MR examination included cine, T<jats:sub>2<\/jats:sub>\u2010short tau inversion recovery (T<jats:sub>2<\/jats:sub>\u2010STIR), first pass perfusiong (FPP)\uff0cphase sensitive inversion recovery (PSIR), and diffusion\u2010weighted imaging (DWI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>SPF values among different myocardium regions (infarcted, salvaged, remote, and MVO) and stages of reperfused STEMI patients as well as normal controls were measured. The diagnostic utility of SPF values in differentiating salvaged and infarcted myocardium was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Analysis<\/jats:title><jats:p>Independent <jats:italic>t<\/jats:italic>\u2010test and the Mann\u2013Whitney <jats:italic>U\u2010<\/jats:italic>test. Logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SPF values in healthy controls were not significantly different than SPF values in the remote myocardium of patients (40.09\u2009\u00b1\u20091.47% vs. 40.28\u2009\u00b1\u20091.93%, <jats:italic>P<\/jats:italic> = 0.698). In reperfusion STEMI patients, SPF values were lower in infarcted myocardium compared to remote and salvaged myocardium (32.15\u2009\u00b1\u20092.36% vs. 40.28\u2009\u00b1\u20091.93%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; 32.15\u2009\u00b1\u20092.36% vs. 36.68\u2009\u00b1\u20092.71%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). SPF values of infarcted myocardium showed a rebound increase from acute to convalescent stages (32.15\u2009\u00b1\u20092.36% vs. 34.69\u2009\u00b1\u20093.69%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). When differentiating infarcted and salvaged myocardium, SPF values demonstrated an area under the curve (AUC) of 0.89 (sensitivity 85.4%, specificity 80.5%, cutoff 34.42%). Lower SPF values were associated with lower odds ratio (OR = 0.304) of left ventricular remodeling after adjusting for potential confounders with a confidence interval (CI) of 0.129\u20130.717, <jats:italic>P<\/jats:italic> = 0.007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>SPF might be able to differentiate salvaged and infarcted myocardium and is a strong predictor of left ventricular remodeling in reperfused STEMI patients.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage<\/jats:bold> 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27310","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T03:28:35Z","timestamp":1598412515000},"page":"516-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic Utility of the Simplified Perfusion Fraction for Identifying Myocardial Injury in Patients With Reperfused <scp>ST<\/scp>\u2010segment Elevation Myocardial Infarction"],"prefix":"10.1002","volume":"53","author":[{"given":"Dong\u2010Aolei","family":"An","sequence":"first","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Teng","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara M.","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong\u2010Tong","family":"Han","sequence":"additional","affiliation":[{"name":"Circle Cardiovascular Imaging  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Rong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian\u2010Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"633","article-title":"The \u201cwavefront phenomenon\u201d of myocardial ischemic cell death. 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