{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:59:21Z","timestamp":1789030761090,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572652"],"award-info":[{"award-number":["81572652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nodal (N) stage is one of the most important predictors for distant metastasis in nasopharyngeal carcinoma (NPC) patients. It may ignore potentially useful nodal features, such as nodal matting (three or more lymph nodes abutting together with the absence of intervening fat planes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the prognostic value of nodal matting in NPC patients and construct a nomogram with nodal matting for predicting distant metastasis\u2010free survival (DMFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 792 NPC patients treated with intensity modulated radiation therapy from 2010 to 2013 were enrolled with 2:1 training (<jats:italic>n =<\/jats:italic> 527) and validation (<jats:italic>n =<\/jats:italic> 65) cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>T<jats:sub>1<\/jats:sub>\u2010 and T<jats:sub>2<\/jats:sub>\u2010weighted imaging at 1.5 or 3.0T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Nodal matting and other nodal characteristics were assessed with MRI. MR images were evaluated separately by three radiologists. The association between nodal matting and DMFS was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Univariate and multivariate analyses were performed using the Cox proportional hazards regression model. Nomograms were constructed from a multivariate logistic regression model with and without nodal matting. The predictive accuracy and discriminative ability of the nomograms were determined by concordance index (C\u2010index) and calibration curves. The results were validated using bootstrap resampling and validation cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of nodal matting was 24.6% (195\/792) in all patients. In the training cohort, nodal matting was independently associated with DMFS (hazard ratio [HR] = 1.97 [1.05\u20133.69], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). N1 patients with nodal matting had worse DMFS than N1 patients without (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, no significant difference was observed when comparing N1 patients with nodal matting to N2 patients (<jats:italic>P<\/jats:italic> = 0.464). The C\u2010index of the nomogram with nodal matting was higher than the nomogram without (0.717 vs. 0.699, <jats:italic>P<\/jats:italic> = 0.084).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Nodal matting was an independent prognostic factor for DMFS in NPC patients. It may help to select patients at high risk of distant metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27339","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T04:54:39Z","timestamp":1598676879000},"page":"152-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic Value of Nodal Matting on <scp>MRI<\/scp> in Nasopharyngeal Carcinoma Patients"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1369-2897","authenticated-orcid":false,"given":"Huali","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiology, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medical Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Ruan","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"ParkinDM MuirCS WhelanSL et al. Cancer incidence in five continents. IARC Scientific Publications No. 120. Lyon France: IARC 1992."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.10.020"},{"key":"e_1_2_7_4_1","first-page":"814948","article-title":"Clinical outcomes and prognostic factors of 695 nasopharyngeal carcinoma patients treated with intensity\u2010modulated radiotherapy","volume":"2014","author":"Wang W","year":"2014","journal-title":"Biomed Res Int"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0167-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.02.003"},{"key":"e_1_2_7_7_1","volume-title":"AJCC cancer staging manual","author":"Amin M","year":"2016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0121"},{"key":"e_1_2_7_9_1","first-page":"546","article-title":"Proposal for the 8th edition of the AJCC\/UICC staging system for nasopharyngeal cancer in the era of intensity\u2010modulated radiotherapy","volume":"122","author":"Pan JJ","year":"2016","journal-title":"Cancer\u2010Am Cancer Soc"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15141251"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0271"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21997"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28237"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.12.1705"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24257"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2005.06.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24105"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23882"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25842"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0968"},{"key":"e_1_2_7_21_1","first-page":"108","article-title":"Establishment and validation of prognostic nomograms for endemic nasopharyngeal carcinoma","volume":"291","author":"Tang L","year":"2015","journal-title":"J Natl Cancer I"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.20255"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.177.2.2217772"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.323.9550"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/53555208"},{"key":"e_1_2_7_27_1","first-page":"161964","article-title":"The prognostic value of lymph node cross\u2010sectional cancer area in node\u2010positive breast cancer: A comparison with N stage and lymph node ratio","volume":"2012","author":"Li Y","year":"2012","journal-title":"Patholog Res Int"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25504"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.05.064"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1858"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4419-1"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.08.004"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.27339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:49:36Z","timestamp":1693810176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.27339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jmri.27339"],"URL":"https:\/\/doi.org\/10.1002\/jmri.27339","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"2020-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}