{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:58:00Z","timestamp":1780430280357,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K01HL121162"],"award-info":[{"award-number":["K01HL121162"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL089695"],"award-info":[{"award-number":["R01HL089695"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R03HL144891"],"award-info":[{"award-number":["R03HL144891"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac MRI is an emerging modality for evaluating left ventricular (LV) diastolic dysfunction (LVDD), a pathological condition that is prevalent in aging populations. However, there is a lack of reports of MRI\u2010derived LV diastolic properties in late diastole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To test the hypothesis that cine MRI\u2010derived motion\/deformation indices can be used to characterize age\u2010related changes on LV relaxation patterns in late diastole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>In all, 412 participants (72.5\u2009\u00b1\u20094.6\u2009years old, range 65\u201384) without a documented history of cardiovascular diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Balanced steady\u2010state free precession(bSSFP) acquired at 1.5T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Participants were divided into younger (65\u201374\u2009years old, <jats:italic>n =<\/jats:italic> 275) and older (75\u201384\u2009years old, <jats:italic>n =<\/jats:italic> 137) groups. Status of diabetes mellitus (DM), hypertension (HTN), and lipid disorders were recorded for each participant. Cine MRI datasets were analyzed by using heart deformation analysis (HDA). LV motion\/deformation indices (displacement, velocity, strain, and strain rate) were measured through 22 phases within a cardiac cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The prevalence of traditional cardiovascular risk conditions, LV ejection fraction (LVEF), peak LV regional displacement, velocity, and strain rates at early and late diastole were compared between two participant groups using chi\u2010square tests or <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Older participants had a significantly lower peak early radial displacement (0.797\u2009\u00b1\u20090.249\u2009cm vs. 0.876\u2009\u00b1\u20090.286 cm), radial velocity (19.3\u2009\u00b1\u20096.3\u2009mm\/s vs. 17.5\u2009\u00b1\u20095.2\u2009mm\/s), and circumferential strain rate (64.6\u2009\u00b1\u200915.7%\/s vs. 70.1\u2009\u00b1\u200917%\/s) but a higher peak late circumferential strain rate (69.8\u2009\u00b1\u200916.3 %\/s vs. 66\u2009\u00b1\u200915.8 %\/s) than their younger counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Cine MRI can be used to characterize age\u2010related LV relaxation patterns in late diastole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>1.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27382","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T09:42:42Z","timestamp":1601631762000},"page":"766-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac <scp>MRI<\/scp> Reveals Late Diastolic Changes in Left Ventricular Relaxation Patterns During Healthy Aging"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-4077","authenticated-orcid":false,"given":"Kai","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Radiology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology Yuhuangding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sarnari","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debiao","family":"Li","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lloyd\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of preventive medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6549-4863","authenticated-orcid":false,"given":"James C.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-018-0372-1"},{"key":"e_1_2_8_3_1","unstructured":"ManningWJ PennellDJ.Cardiovascular magnetic resonance 3rd Edition: A companion to Braunwald's heart disease.2019:282\u2010290."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet189"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcy088"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-13-36"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2016.08.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0517-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.08.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-0879-z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2015.10.020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-28326-0_10"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","unstructured":"GuetterCX H.Chefd'hotel C.Guehring J. 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