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However, most studies have only focused on functional connectivity (FC) alterations in gray matter (GM), and the functional alterations in white matter (WM) remain largely unknown in MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate WM functional alterations and the functional interaction between GM and WM networks in medication\u2010na\u00efve MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Sixty\u2010eight patients with MDD and 66 age\u2010 and sex\u2010matched healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Resting state\u2010functional MRI (fMRI) using a gradient\u2010echo imaging sequence and T<jats:sub>1<\/jats:sub>\u2010weighted images were acquired at 3.0T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Functional GM and WM networks, based on resting\u2010state blood oxygenation level\u2010dependent (BOLD) signals, were identified by the K\u2010means clustering algorithm, and FC matrices were obtained for each subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Two\u2010sample <jats:italic>t<\/jats:italic>\u2010tests, Pearson chi\u2010square test, and Pearson correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the GM and WM of the visual network (GM1 and WM11) showed reduced FC with the sensorimotor network (WM5 and GM8), lateral temporal network (GM5 and WM6), cingulo\u2010opercular network (GM9), and dorsal attention network (GM7) in MDD patients compared to controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, false discovery rate [FDR]\u2010corrected). Reduced FC between the anterior cingulum network (WM3) and the lateral temporal network (GM5 and WM6) and temporal pole network (GM13) and between GM13 and the medial temporal network (GM4) and medial prefrontal\u2010subcortical network (GM10) were also observed in MDD patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, FDR\u2010corrected). In addition, the WM BOLD signal in the sensorimotor network was negatively correlated with illness duration (<jats:italic>r =<\/jats:italic> \u20130.286, <jats:italic>P<\/jats:italic> = 0.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Disconnectivity between the GM and WM networks in the perception\u2010motor system may be the foundation of extensively disrupted connections in MDD. Furthermore, the observed decoupling between subsystems of the default mode network may help explain previous findings of persistent negative rumination and theory of mind deficits in depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27392","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T07:20:19Z","timestamp":1602487219000},"page":"742-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Decoupling of Gray and White Matter Functional Networks in Medication\u2010Na\u00efve Patients With Major Depressive Disorder"],"prefix":"10.1002","volume":"53","author":[{"given":"Youjin","family":"Zhao","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-1769","authenticated-orcid":false,"given":"Su","family":"Lui","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra073096"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","volume-title":"Psychoradiology","author":"Q. 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