{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:30:28Z","timestamp":1791487828769,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004361","name":"Krebsliga Schweiz","doi-asserted-by":"publisher","award":["KFS\u20103975\u2010082016\u2010R"],"award-info":[{"award-number":["KFS\u20103975\u2010082016\u2010R"]}],"id":[{"id":"10.13039\/501100004361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with steno\u2010occlusive disease, recent findings suggest that hemodynamic alterations may also be associated with crossed cerebellar diaschisis (CCD) rather than a functional disruption alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To use a quantitative multiparametric hemodynamic MRI to gain a better understanding of hemodynamic changes related to CCD in patients with unilateral anterior circulation stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010four patients (25 datasets) with symptomatic unilateral anterior circulation stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T\/two sequences: single\u2010shot (echo\u2010planar imaging) EPI sequence and T<jats:sub>2<\/jats:sub><jats:sup>*<\/jats:sup>gradient echo perfusion\u2010weighted imaging study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The presence of CCD was inferred from the cerebellar asymmetry index (CAI) of the blood oxygenation\u2010level dependent cerebrovascular reactivity (BOLD\u2010CVR) exam, which was calculated from the mean BOLD\u2010CVR and standard deviation of the CAI of the healthy control group. For all perfusion\u2010weighted (PW)\u2010MRI parameters, the cerebellar and middle cerebral artery (MCA) territory asymmetry indices were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Independent Student's<jats:italic>t<\/jats:italic>\u2010test to compare the variables from the CCD positive(+) and CCD negative(\u2013) groups and analysis of covariance (ANCOVA) to statistically control the effect of covariates (infarct volume and time since ischemia onset).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CCD was present in 33% of patients. In the MCA territory of the affected hemisphere, BOLD\u2010CVR was significantly more impaired in the CCD(+) group as compared to the CCD(\u2013) group (mean BOLD\u2010CVR\u2009\u00b1\u2009SD [%BOLD signal\/\u0394mmHgCO<jats:sub>2<\/jats:sub>]: \u20130.03\u2009\u00b1\u20090.12 vs. 0.11\u2009\u00b1\u20090.13,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the mean transit time (MTT) (asymmetry index (%) CCD(+) vs. CCD(\u2013): 28\u2009\u00b1\u200923 vs. 4\u2009\u00b1\u200911,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and time to peak (TTP) (10\u2009\u00b1\u200910 vs. 2\u2009\u00b1\u20095,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in the MCA territory of the affected hemisphere were significantly prolonged, while cerebral blood volume was, on average, increased in the CCD(+) group (25\u2009\u00b1\u200915 vs. 4\u2009\u00b1\u200919,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Our findings show that, in patients with symptomatic unilateral anterior circulation stroke, CCD is associated with hemodynamic impairment in the ipsilateral MCA territory, which further supports the concept of a vascular component of CCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27410","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T06:48:16Z","timestamp":1603954096000},"page":"1190-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Crossed Cerebellar Diaschisis in Patients With Symptomatic Unilateral Anterior Circulation Stroke Is Associated With Hemodynamic Impairment in the Ipsilateral<scp>MCA<\/scp>Territory"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-3421","authenticated-orcid":false,"given":"Martina","family":"Seb\u00f6k","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University Hospital Zurich, University of Zurich Zurich Switzerland"},{"name":"Clinical Neuroscience Center University Hospital Zurich Zurich 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