{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:59:27Z","timestamp":1774450767024,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Differentiating nasopharyngeal carcinoma (NPC) from nasopharyngeal lymphoma (NPL) is useful for deciding the appropriate treatment. However, the diagnostic accuracy of current imaging methods is low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the feasibility of arterial spin labeling (ASL) perfusion imaging in the qualitative and quantitative differentiation between NPC and NPL to improve the diagnosis of malignancies in the nasopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Ninety seven patients: NPC (65 cases) and NPL (32 cases), histologically confirmed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3T\/<jats:styled-content style=\"fixed-case\">3D<\/jats:styled-content> fast spin echo pseudo\u2010continuous <jats:styled-content style=\"fixed-case\">ASL<\/jats:styled-content> imaging with spiral readout scheme, <jats:styled-content style=\"fixed-case\">3D<\/jats:styled-content> inverse recovery<jats:sub>\u2013<\/jats:sub>fast spoiled gradient recalled echo brain volume (<jats:styled-content style=\"fixed-case\">BRAVO)<\/jats:styled-content> imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Cerebral blood flow (CBF) images from ASL perfusion imaging were assessed by three radiologists. Each tumor was visually scored based on CBF images. Intratumoral CBF and intramuscular CBF values were obtained from intratumoral and lateral pterygoid muscle areas, respectively. Through dividing intratumoral CBF by intramuscular CBF, normalized CBF (nCBF) was further calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Fleiss's kappa and intraclass correlation coefficients (ICCs) were used to assess interobserver agreement among the three readers. The Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test was used to compare visual scoring, and an unpaired <jats:italic>t<\/jats:italic>\u2010test was performed to compare CBF value between the NPC and NPL groups. The area under the curve (AUC) value was used to quantify the diagnostic ability of each parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Good interobserver agreements were validated by high Fleiss's kappa and ICC values (all &gt;0.80). NPCs showed significantly higher visual scores than NPLs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Both intratumoral CBF and nCBF in NPC were significantly higher than those in NPL (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Intratumoral CBF showed the highest AUC of 0.861 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in differentiating NPC (<jats:italic>n<\/jats:italic> = 65) from NPL (<jats:italic>n<\/jats:italic> = 32), while the AUCs of nCBF and visual scoring were 0.847 and 0.753, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>For the diagnosis of distinguishing NPC from NPL, ASL perfusion imaging demonstrated high diagnostic efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27451","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T22:30:11Z","timestamp":1606170611000},"page":"1140-1148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Can Arterial Spin Labeling Perfusion Imaging be Used to Differentiate Nasopharyngeal Carcinoma From Nasopharyngeal Lymphoma?"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-9925","authenticated-orcid":false,"given":"Zongqiong","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Jiangnan University  Wuxi City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shudong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Jiangnan University  Wuxi City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxi","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Jiangnan University  Wuxi City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linfang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated 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